Naoyuki Himi1, Hisashi Takahashi2, Naohiko Okabe1, Emi Nakamura1, Takashi Shiromoto3, Kazuhiko Narita1, Tomoshige Koga2, Osamu Miyamoto4. 1. Second Department of Physiology, Kawasaki Medical School, Kurashiki, Okayama, Japan. 2. Department of Rehabilitation, Kawasaki University of Medical Welfare, Kurashiki, Okayama, Japan. 3. Department of Stroke, Kawasaki Medical School, Kurashiki, Okayama, Japan. 4. Second Department of Physiology, Kawasaki Medical School, Kurashiki, Okayama, Japan. Electronic address: mosamu@med.kawasaki-m.ac.jp.
Abstract
BACKGROUND: Exercise in the early stage after stroke onset has been shown to facilitate the recovery from physical dysfunction. However, the mechanism of recovery has not been clarified. In this study, the effect of exercise on spatial memory function recovery in the early stage was shown, and the mechanism of recovery was discussed using a rat model of brain embolism. METHODS: Intra-arterial microsphere (MS) injection induced small emboli in the rat brain. Treadmill exercise was started at 24 hours (early group) or 8 days (late group) after MS injection. The non-exercise (NE) and sham-operated groups were included as controls. Memory function was evaluated by the Morris water maze test, and hippocampal levels of brain-derived neurotrophic factor (BDNF) were measured by enzyme-linked immunosorbent assays. To further investigate the effect of BDNF on memory function, BDNF was continuously infused into the hippocampus via implantable osmotic pumps in the early or late stage after stroke. RESULTS: Memory function significantly improved only in the early group compared with the late and the NE groups, although hippocampal BDNF concentrations were temporarily elevated after exercise in both the early and the late groups. Rats infused with BDNF in the early stage exhibited significant memory function recovery; however, rats that received BDNF infusion in the late stage showed no improvement. CONCLUSION: Exercise elevates hippocampal BDNF levels in the early stage after cerebral embolism, and this event facilitates memory function recovery.
BACKGROUND: Exercise in the early stage after stroke onset has been shown to facilitate the recovery from physical dysfunction. However, the mechanism of recovery has not been clarified. In this study, the effect of exercise on spatial memory function recovery in the early stage was shown, and the mechanism of recovery was discussed using a rat model of brain embolism. METHODS: Intra-arterial microsphere (MS) injection induced small emboli in the rat brain. Treadmill exercise was started at 24 hours (early group) or 8 days (late group) after MS injection. The non-exercise (NE) and sham-operated groups were included as controls. Memory function was evaluated by the Morris water maze test, and hippocampal levels of brain-derived neurotrophic factor (BDNF) were measured by enzyme-linked immunosorbent assays. To further investigate the effect of BDNF on memory function, BDNF was continuously infused into the hippocampus via implantable osmotic pumps in the early or late stage after stroke. RESULTS: Memory function significantly improved only in the early group compared with the late and the NE groups, although hippocampal BDNF concentrations were temporarily elevated after exercise in both the early and the late groups. Rats infused with BDNF in the early stage exhibited significant memory function recovery; however, rats that received BDNF infusion in the late stage showed no improvement. CONCLUSION: Exercise elevates hippocampal BDNF levels in the early stage after cerebral embolism, and this event facilitates memory function recovery.
Authors: Mansour Sayyah; Mehdi Seydyousefi; Abdorreza Eghbal Moghanlou; Gerlinde A S Metz; Nabi Shamsaei; Mohammad Hasan Faghfoori; Zeinab Faghfoori Journal: Metab Brain Dis Date: 2022-05-21 Impact factor: 3.655
Authors: Carolina C Alcantara; Luisa F García-Salazar; Marcela A Silva-Couto; Gabriela L Santos; Darcy S Reisman; Thiago L Russo Journal: Front Neurol Date: 2018-08-28 Impact factor: 4.003