| Literature DB >> 27639156 |
Ji-Qing Chen1, Gábor Papp1, Péter Szodoray2, Margit Zeher3.
Abstract
MicroRNAs (miRNAs) are single-stranded, endogenous non-coding small RNAs, ranging from 18 to 25 nucleotides in length. Growing evidence suggests that miRNAs are essential in regulating gene expression, cell development, differentiation and function. Autoimmune diseases are a family of chronic systemic inflammatory diseases. Recent findings on miRNA expression profiles have been suggesting their role as biomarkers in autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and Sjögren's syndrome. In this review, we summarize the characteristics of miRNAs and their functional role in the immune system and autoimmune diseases including systemic lupus erythematosus, primary Sjögren's syndrome, rheumatoid arthritis, systemic sclerosis, multiple sclerosis and psoriasis; moreover, we depict the advantages of miRNAs in modern diagnostics.Entities:
Keywords: MicroRNAs (miRs); Multiple sclerosis (MS); Primary Sjögren's syndrome (SS); Psoriasis; Rheumatoid arthritis (RA); Systemic lupus erythematosus (SLE); Systemic sclerosis (SSc)
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Year: 2016 PMID： 27639156 DOI： 10.1016/j.autrev.2016.09.003
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754