Marisa Toups1, Thomas Carmody2, Madhukar H Trivedi1, A John Rush3, S Susan Hedayati4. 1. Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, USA, 75390-9119. 2. Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, USA, 75390-9119; Division of Biostatistics, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, USA, 75390-9066. 3. Division of Clinical Sciences, Duke-NUS, 8 College Rd, Singapore, 169857. 4. Division of Nephrology, Department of Medicine, Veterans Affairs North Texas Health Care System, 4500 S. Lancaster Rd MC 111G1, Dallas, TX, USA, 75216; Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, USA, 75390-8516. Electronic address: susan.hedayati@utsouthwestern.edu.
Abstract
OBJECTIVE: Because there is overlap between somatic symptoms of depression and symptoms of chronic kidney disease (CKD), it is unclear if self-reported depression rating scales can be used accurately in predialysis CKD patients, especially if CKD and other comorbidities are symptomatic. We assessed the performance of two depression scales - the Beck Depression Inventory (BDI) and the Quick Inventory of Depression Symptomatology (QIDS-SR16) - by CKD stage, diagnosis of diabetes and total medical comorbidity burden - using item response theory (IRT) in a sample of 272 predialysis CKD patients. METHODS: We performed IRT by low versus high CKD stage, diabetes versus no diabetes and high (>3 diagnoses) versus low medical comorbidity burden. RESULTS: IRT models of each rating scale were affected in a limited way by CKD stage, diabetes and medical comorbidity burden. Sleep disturbances on the QIDS-SR16 were more discriminatory for depression in diabetics and those with high comorbidity burden. Pessimism and guilt from the BDI compared to QIDS-SR16 were more discriminatory of depression in the high CKD and high comorbidity groups, respectively. CONCLUSIONS: Overall item differences were modest, and chronic disease severity by CKD stage, diabetes mellitus or other medical comorbidities did not appreciably contribute to differences in scale performance.
OBJECTIVE: Because there is overlap between somatic symptoms of depression and symptoms of chronic kidney disease (CKD), it is unclear if self-reported depression rating scales can be used accurately in predialysis CKD patients, especially if CKD and other comorbidities are symptomatic. We assessed the performance of two depression scales - the Beck Depression Inventory (BDI) and the Quick Inventory of Depression Symptomatology (QIDS-SR16) - by CKD stage, diagnosis of diabetes and total medical comorbidity burden - using item response theory (IRT) in a sample of 272 predialysis CKD patients. METHODS: We performed IRT by low versus high CKD stage, diabetes versus no diabetes and high (>3 diagnoses) versus low medical comorbidity burden. RESULTS: IRT models of each rating scale were affected in a limited way by CKD stage, diabetes and medical comorbidity burden. Sleep disturbances on the QIDS-SR16 were more discriminatory for depression in diabetics and those with high comorbidity burden. Pessimism and guilt from the BDI compared to QIDS-SR16 were more discriminatory of depression in the high CKD and high comorbidity groups, respectively. CONCLUSIONS: Overall item differences were modest, and chronic disease severity by CKD stage, diabetes mellitus or other medical comorbidities did not appreciably contribute to differences in scale performance.
Authors: Laura Plantinga; Kathryn Lee; Lesley A Inker; Rajiv Saran; Jerry Yee; Brenda Gillespie; Deborah Rolka; Sharon Saydah; Neil R Powe Journal: Am J Kidney Dis Date: 2011-08-04 Impact factor: 8.860
Authors: Suetonia Palmer; Mariacristina Vecchio; Jonathan C Craig; Marcello Tonelli; David W Johnson; Antonio Nicolucci; Fabio Pellegrini; Valeria Saglimbene; Giancarlo Logroscino; Steven Fishbane; Giovanni F M Strippoli Journal: Kidney Int Date: 2013-03-13 Impact factor: 10.612
Authors: S Susan Hedayati; Hayden B Bosworth; Libbie P Briley; Richard J Sloane; Carl F Pieper; Paul L Kimmel; Lynda A Szczech Journal: Kidney Int Date: 2008-06-25 Impact factor: 10.612