Natalya Lisovska1, Zholtay Daribayev2, Yevgeny Lisovskyy2, Kenzhe Kussainova2, Lana Austin3, Sholpan Bulekbayeva2. 1. Republican Children's Rehabilitation Center, Turan str., 36, Astana, Kazakhstan, 010000. lisovska67@mail.ru. 2. Republican Children's Rehabilitation Center, Turan str., 36, Astana, Kazakhstan, 010000. 3. Department of Pediatrics, Parirenyatwa Group of hospitals, Harare, Zimbabwe.
Abstract
BACKGROUND: The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability. Though the great progress in the neuroscience has been recently achieved, the pathogenesis of cerebral palsy is still poorly understood. METHODS: In this work, we reviewed available experimental and clinical data concerning the role of immune cells in pathogenesis of cerebral palsy. Maintaining of homeostasis in nervous tissue and its transformation in case of periventricular leukomalacia were analyzed. RESULTS: The reviewed data demonstrate involvement of immune regulatory cells in the formation of nervous tissue imbalance and chronicity of inborn brain damage. The supported opinion, that periventricular leukomalacia is not a static phenomenon, but developing process, encourages our optimism about the possibility of its correction. CONCLUSIONS: The further studies of changes of the nervous and immune systems in cerebral palsy are needed to create fundamentally new directions of the specific therapy and individual schemes of rehabilitation.
BACKGROUND: The cerebral palsy is highly actual issue of pediatrics, causing significant neurological disability. Though the great progress in the neuroscience has been recently achieved, the pathogenesis of cerebral palsy is still poorly understood. METHODS: In this work, we reviewed available experimental and clinical data concerning the role of immune cells in pathogenesis of cerebral palsy. Maintaining of homeostasis in nervous tissue and its transformation in case of periventricular leukomalacia were analyzed. RESULTS: The reviewed data demonstrate involvement of immune regulatory cells in the formation of nervous tissue imbalance and chronicity of inborn brain damage. The supported opinion, that periventricular leukomalacia is not a static phenomenon, but developing process, encourages our optimism about the possibility of its correction. CONCLUSIONS: The further studies of changes of the nervous and immune systems in cerebral palsy are needed to create fundamentally new directions of the specific therapy and individual schemes of rehabilitation.
Authors: Sterling B Ortega; Xiagmei Kong; Ramgopal Venkataraman; Allen Michael Savedra; Steven G Kernie; Ann M Stowe; Lakshmi Raman Journal: J Leukoc Biol Date: 2015-06-02 Impact factor: 4.962
Authors: Jonathan P Etter; Sanjana Kannikeswaran; Edward A Hurvitz; Mark D Peterson; Michelle S Caird; Karl J Jepsen; Daniel G Whitney Journal: Bone Rep Date: 2020-10-27