Ashley B Simpson1, Devina McCray2, Craig Wengler2, Joseph P Crowe2, Risal Djohan3, Rahul Tendulkar4, Colin O'Rourke5, Stephen R Grobmyer2, Stephanie A Valente2. 1. Department of General Surgery, Division of Breast Services, Cleveland Clinic Foundation, Cleveland, OH, USA. simpsoa@ccf.org. 2. Department of General Surgery, Division of Breast Services, Cleveland Clinic Foundation, Cleveland, OH, USA. 3. Department of Plastic of Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA. 4. Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH, USA. 5. Quantitative Health Services, Cleveland Clinic Foundation, Cleveland, OH, USA.
Abstract
BACKGROUND: Inflammatory breast cancer (IBC) is an aggressive disease that is treated with trimodality therapy consisting of neoadjuvant chemotherapy, surgery, and post-mastectomy radiation therapy (PMRT). Traditionally, modified radical mastectomy without reconstruction has been the operation of choice for patients with IBC due to fears of high rates of margin positivity, risk of local recurrence, and the need for PMRT. METHODS: A retrospective review was performed to evaluate women with IBC at our institution from 2006 to 2014 who completed trimodality therapy. Patients were identified as undergoing reconstruction or no reconstruction (NR), with reconstruction being further classified as immediate (IR) if reconstruction occurred at the initial surgery, or delayed (DR) if initial reconstruction occurred after PMRT. RESULTS: Sixty women with IBC were identified using inclusion criteria. The median follow-up was 2.3 years (range 1.4-4.6). Patients with IR had a statistically significant increased risk (p = 0.006) in postoperative complication rates compared with DR (0 %) and NR (2.6 %). Two patients had positive skin margins on final pathology (one IR, one NR), with both eventually having recurrence. Time to PMRT was delayed 10 days in patients with IR compared with those without IR. No statistically significant difference in recurrence rates was observed (p = 0.86) when comparing patients with IR and those with NR, and no difference in survival was observed between patients who had reconstruction and those without (p = 0.91). CONCLUSION: Performing IR with mastectomy for IBC is associated with increased complications, but is not associated with decreased survival or increased recurrence in selected patients. IR in selected IBC patients can facilitate successful breast reconstruction.
BACKGROUND: Inflammatory breast cancer (IBC) is an aggressive disease that is treated with trimodality therapy consisting of neoadjuvant chemotherapy, surgery, and post-mastectomy radiation therapy (PMRT). Traditionally, modified radical mastectomy without reconstruction has been the operation of choice for patients with IBC due to fears of high rates of margin positivity, risk of local recurrence, and the need for PMRT. METHODS: A retrospective review was performed to evaluate women with IBC at our institution from 2006 to 2014 who completed trimodality therapy. Patients were identified as undergoing reconstruction or no reconstruction (NR), with reconstruction being further classified as immediate (IR) if reconstruction occurred at the initial surgery, or delayed (DR) if initial reconstruction occurred after PMRT. RESULTS: Sixty women with IBC were identified using inclusion criteria. The median follow-up was 2.3 years (range 1.4-4.6). Patients with IR had a statistically significant increased risk (p = 0.006) in postoperative complication rates compared with DR (0 %) and NR (2.6 %). Two patients had positive skin margins on final pathology (one IR, one NR), with both eventually having recurrence. Time to PMRT was delayed 10 days in patients with IR compared with those without IR. No statistically significant difference in recurrence rates was observed (p = 0.86) when comparing patients with IR and those with NR, and no difference in survival was observed between patients who had reconstruction and those without (p = 0.91). CONCLUSION: Performing IR with mastectomy for IBC is associated with increased complications, but is not associated with decreased survival or increased recurrence in selected patients. IR in selected IBC patients can facilitate successful breast reconstruction.
Authors: Ananya Gopika Nair; Vasily Giannakeas; John L Semple; Steven A Narod; David W Lim Journal: Ann Surg Oncol Date: 2022-09-08 Impact factor: 4.339
Authors: Daniel I Hoffman; Patricia Mae G Santos; Macy Goldbach; Luke J Keele; Neil K Taunk; Hannah S Bogen; Laura Burkbauer; Rachel C Jankowitz; Joshua Fosnot; Liza C Wu; Gary M Freedman; Julia C Tchou Journal: Ann Surg Oncol Date: 2021-07-16 Impact factor: 5.344
Authors: René Aloisio da Costa Vieira; Luciana Machado Ribeiro; Guilherme Freire Angotti Carrara; Lucas Faria Abrahão-Machado; Ligia Maria Kerr; Afonso Celso Pinto Nazário Journal: Breast Care (Basel) Date: 2019-05-03 Impact factor: 2.860
Authors: Kate R Pawloski; Andrea V Barrio; Mary L Gemignani; Varadan Sevilimedu; Tiana Le; Joseph Dayan; Monica Morrow; Audree B Tadros Journal: J Am Coll Surg Date: 2021-05-03 Impact factor: 6.532
Authors: Murad J Karadsheh; Jacob Y Katsnelson; Karen J Ruth; Eric S Weiss; James C Krupp; Elin R Sigurdson; Richard J Bleicher; Marilyn Ng; M Shuja Shafqat; Sameer A Patel Journal: Plast Reconstr Surg Glob Open Date: 2021-04-15