Yeda Chen1, Jingtang Zeng1, Yiqing Tan1, Min Feng1, Jiheng Qin1, Meihua Lin1, Xiang Zhao1, Xiaolei Zhao1, Yan Liang2, Naizun Zhang2, Shaoqi Rao3. 1. Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China. 2. Maoming People's Hospital, Maoming, Guangdong, China. 3. Institute of Medical Systems Biology, and School of Public Health, Guangdong Medical University, No. 1 New City Avenue, Songshan Lake Science and Technology Industry Park, 523808, Dongguan, Guangdong, China. raoshaoq@gdmc.edu.cn.
Abstract
OBJECTIVE: The study was carried out to examine the association between apolipoprotein B (ApoB) EcoRI polymorphism (E- vs. E+) (rs1042031) and coronary heart disease (CHD) risk by systematically analyzing multiple independent studies. METHODS: The Hardy-Weinberg equilibrium (HWE) test was applied to assess genotype frequency distribution in healthy controls. The quality of the studies was assessed using the Newcastle-Ottawa scale (NOS). Power analysis was performed with Power and Precision V4 software. A fixed effect model was used because no deviation from homogeneity was found. Publication bias was quantified and examined with Begg's funnel plot test and Egger's linear regression method. The meta-analysis was performed by Stata 12.0 software. RESULTS: A total of 21 eligible association studies were merged in this meta-analysis and the pooled sample consisted of 2994 CHD patients and 3258 healthy controls. No significant publication bias and heterogeneity were observed in these studies. The pooled odds ratio (OR) and 95% confidence interval (CI) of E- vs. E+ were 1.18 (1.06-1.32). The pooled OR (95% CI) of E+ E- + E- E- vs. E+ E+ was 1.18 (1.04-1.34). CONCLUSIONS: This meta-analysis indicated that ApoB EcoRI confers a moderate risk for CHD and the E- allele at this locus might be a susceptibility allele for the development of CHD.
OBJECTIVE: The study was carried out to examine the association between apolipoprotein B (ApoB) EcoRI polymorphism (E- vs. E+) (rs1042031) and coronary heart disease (CHD) risk by systematically analyzing multiple independent studies. METHODS: The Hardy-Weinberg equilibrium (HWE) test was applied to assess genotype frequency distribution in healthy controls. The quality of the studies was assessed using the Newcastle-Ottawa scale (NOS). Power analysis was performed with Power and Precision V4 software. A fixed effect model was used because no deviation from homogeneity was found. Publication bias was quantified and examined with Begg's funnel plot test and Egger's linear regression method. The meta-analysis was performed by Stata 12.0 software. RESULTS: A total of 21 eligible association studies were merged in this meta-analysis and the pooled sample consisted of 2994 CHD patients and 3258 healthy controls. No significant publication bias and heterogeneity were observed in these studies. The pooled odds ratio (OR) and 95% confidence interval (CI) of E- vs. E+ were 1.18 (1.06-1.32). The pooled OR (95% CI) of E+ E- + E- E- vs. E+ E+ was 1.18 (1.04-1.34). CONCLUSIONS: This meta-analysis indicated that ApoB EcoRI confers a moderate risk for CHD and the E- allele at this locus might be a susceptibility allele for the development of CHD.
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