Literature DB >> 27636649

T cells in Systemic Lupus Erythematosus.

Abel Suárez-Fueyo1, Sean J Bradley2, George C Tsokos3.   

Abstract

Systemic Lupus Erythematosus is an autoimmune disorder caused by a complex combination of genetic, epigenetic and environmental factors. Different polymorphisms and epigenetic modifications lead to altered gene expression and function of several molecules which lead to abnormal T cell responses. Metabolic and functional alterations result in peripheral tolerance failures and biased differentiation of T cells into pro-inflammatory and B cell-helper phenotypes as well as the accumulation of disease-promoting memory T cells. Understanding these T cell alterations and their origins is necessary to develop more accurate patient classification systems and to discover new therapeutic targets. Copyright Â
© 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27636649      PMCID： PMC5125867          DOI： 10.1016/j.coi.2016.09.001

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  65 in total

1.  Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosus.

Authors:  Hiroshi Kato; Andras Perl
Journal:  J Immunol       Date:  2014-03-28       Impact factor: 5.422

2.  Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus.

Authors:  William E O'Gorman; Elena W Y Hsieh; Erica S Savig; Pier Federico Gherardini; Joseph D Hernandez; Leo Hansmann; Imelda M Balboni; Paul J Utz; Sean C Bendall; Wendy J Fantl; David B Lewis; Garry P Nolan; Mark M Davis
Journal:  J Allergy Clin Immunol       Date:  2015-05-30       Impact factor: 10.793

Review 3.  T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity.

Authors:  Vaishali R Moulton; George C Tsokos
Journal:  J Clin Invest       Date:  2015-05-11       Impact factor: 14.808

4.  OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.

Authors:  Clément Jacquemin; Nathalie Schmitt; Cécile Contin-Bordes; Yang Liu; Priya Narayanan; Julien Seneschal; Typhanie Maurouard; David Dougall; Emily Spence Davizon; Hélène Dumortier; Isabelle Douchet; Loïc Raffray; Christophe Richez; Estibaliz Lazaro; Pierre Duffau; Marie-Elise Truchetet; Liliane Khoryati; Patrick Mercié; Lionel Couzi; Pierre Merville; Thierry Schaeverbeke; Jean-François Viallard; Jean-Luc Pellegrin; Jean-François Moreau; Sylviane Muller; Sandy Zurawski; Robert L Coffman; Virginia Pascual; Hideki Ueno; Patrick Blanco
Journal:  Immunity       Date:  2015-06-09       Impact factor: 31.745

5.  The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients.

Authors:  Katsue Sunahori; Kamalpreet Nagpal; Christian M Hedrich; Masayuki Mizui; Lisa M Fitzgerald; George C Tsokos
Journal:  J Biol Chem       Date:  2013-06-17       Impact factor: 5.157

6.  Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling.

Authors:  Sokratis A Apostolidis; Thomas Rauen; Christian M Hedrich; George C Tsokos; José C Crispín
Journal:  J Biol Chem       Date:  2013-08-05       Impact factor: 5.157

7.  Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.

Authors:  Mathieu Gigoux; Jijun Shang; Youngshil Pak; Minghong Xu; Jongseon Choe; Tak W Mak; Woong-Kyung Suh
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-13       Impact factor: 11.205

8.  Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue.

Authors:  Vladimir M Liarski; Natalya Kaverina; Anthony Chang; Daniel Brandt; Denisse Yanez; Lauren Talasnik; Gianluca Carlesso; Ronald Herbst; Tammy O Utset; Christine Labno; Yahui Peng; Yulei Jiang; Maryellen L Giger; Marcus R Clark
Journal:  Sci Transl Med       Date:  2014-04-02       Impact factor: 17.956

Review 9.  Inflammatory cytokines in systemic lupus erythematosus.

Authors:  Kim Ohl; Klaus Tenbrock
Journal:  J Biomed Biotechnol       Date:  2011-10-16

10.  Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus.

Authors:  Zhi-Wei Lai; Rebecca Borsuk; Ashwini Shadakshari; Jianghong Yu; Maha Dawood; Ricardo Garcia; Lisa Francis; Hajra Tily; Adam Bartos; Stephen V Faraone; Paul Phillips; Andras Perl
Journal:  J Immunol       Date:  2013-08-02       Impact factor: 5.422
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  56 in total

1.  T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice.

Authors:  Wei Li; Ahmed S Elshikha; Caleb Cornaby; Xiangyu Teng; Georges Abboud; Josephine Brown; Xueyang Zou; Leilani Zeumer-Spataro; Brian Robusto; Seung-Chul Choi; Kristianna Fredenburg; Amy Major; Laurence Morel
Journal:  JCI Insight       Date:  2020-06-04

2.  Expansion of regulatory T cells using low-dose interleukin-2 attenuates hypertension in an experimental model of systemic lupus erythematosus.

Authors:  Erin B Taylor; Jennifer M Sasser; Kenji J Maeda; Michael J Ryan
Journal:  Am J Physiol Renal Physiol       Date:  2019-03-20

Review 3.  Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective.

Authors:  Vaishali R Moulton; Abel Suarez-Fueyo; Esra Meidan; Hao Li; Masayuki Mizui; George C Tsokos
Journal:  Trends Mol Med       Date:  2017-06-13       Impact factor: 11.951

4.  High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways.

Authors:  Ze Xiu Xiao; Xiaojiang Hu; Ximei Zhang; Zhigang Chen; Julie Wang; Ke Jin; Feng Lin Cao; Baoqing Sun; Joseph A Bellanti; Nancy Olsen; Song Guo Zheng
Journal:  Signal Transduct Target Ther       Date:  2020-04-10

Review 5.  Metabolic determinants of lupus pathogenesis.

Authors:  Xiangyu Teng; Josephine Brown; Seung-Chul Choi; Wei Li; Laurence Morel
Journal:  Immunol Rev       Date:  2020-03-12       Impact factor: 12.988

Review 6.  The spectrum of T cell metabolism in health and disease.

Authors:  Glenn R Bantug; Lorenzo Galluzzi; Guido Kroemer; Christoph Hess
Journal:  Nat Rev Immunol       Date:  2017-09-25       Impact factor: 53.106

Review 7.  New Trials in Lupus and where Are we Going.

Authors:  Aikaterini Thanou; Joan T Merrill
Journal:  Curr Rheumatol Rep       Date:  2018-05-03       Impact factor: 4.592

Review 8.  T cells and autoimmune kidney disease.

Authors:  Abel Suárez-Fueyo; Sean J Bradley; David Klatzmann; George C Tsokos
Journal:  Nat Rev Nephrol       Date:  2017-03-13       Impact factor: 28.314

9.  An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.

Authors:  Ekaterina V Vinogradova; Xiaoyu Zhang; David Remillard; Daniel C Lazar; Radu M Suciu; Yujia Wang; Giulia Bianco; Yu Yamashita; Vincent M Crowley; Michael A Schafroth; Minoru Yokoyama; David B Konrad; Kenneth M Lum; Gabriel M Simon; Esther K Kemper; Michael R Lazear; Sifei Yin; Megan M Blewett; Melissa M Dix; Nhan Nguyen; Maxim N Shokhirev; Emily N Chin; Luke L Lairson; Bruno Melillo; Stuart L Schreiber; Stefano Forli; John R Teijaro; Benjamin F Cravatt
Journal:  Cell       Date:  2020-07-29       Impact factor: 41.582

Review 10.  Importance of lymphocyte-stromal cell interactions in autoimmune and inflammatory rheumatic diseases.

Authors:  Mélissa Noack; Pierre Miossec
Journal:  Nat Rev Rheumatol       Date:  2021-08-03       Impact factor: 20.543
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