Literature DB >> 27636373

The emerging role of serum/glucocorticoid-regulated kinases in cancer.

Pau Castel1, Maurizio Scaltriti1,2.   

Abstract

Entities:  

Keywords:  AKT; PI3K inhibitors; PIK3CA; SGK1; TSC2; drug resistance; mTORC1

Mesh：

Substances：

Year:  2016        PMID： 27636373      PMCID： PMC5270517          DOI： 10.1080/15384101.2016.1232071

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


× No keyword cloud information.
  7 in total

1.  Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.

Authors:  M K Webster; L Goya; Y Ge; A C Maiyar; G L Firestone
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

2.  AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

Authors:  Krishna M Vasudevan; David A Barbie; Michael A Davies; Rosalia Rabinovsky; Chontelle J McNear; Jessica J Kim; Bryan T Hennessy; Hsiuyi Tseng; Panisa Pochanard; So Young Kim; Ian F Dunn; Anna C Schinzel; Peter Sandy; Sebastian Hoersch; Qing Sheng; Piyush B Gupta; Jesse S Boehm; Jan H Reiling; Serena Silver; Yiling Lu; Katherine Stemke-Hale; Bhaskar Dutta; Corwin Joy; Aysegul A Sahin; Ana Maria Gonzalez-Angulo; Ana Lluch; Lucia E Rameh; Tyler Jacks; David E Root; Eric S Lander; Gordon B Mills; William C Hahn; William R Sellers; Levi A Garraway
Journal:  Cancer Cell       Date:  2009-07-07       Impact factor: 31.743

3.  mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

Authors:  Juan M García-Martínez; Dario R Alessi
Journal:  Biochem J       Date:  2008-12-15       Impact factor: 3.857

Review 4.  Sgk kinases and their role in epithelial transport.

Authors:  Johannes Loffing; Sandra Y Flores; Olivier Staub
Journal:  Annu Rev Physiol       Date:  2006       Impact factor: 19.318

5.  The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.

Authors:  Ruzica Bago; Eeva Sommer; Pau Castel; Claire Crafter; Fiona P Bailey; Natalia Shpiro; José Baselga; Darren Cross; Patrick A Eyers; Dario R Alessi
Journal:  EMBO J       Date:  2016-08-01       Impact factor: 11.598

6.  Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

Authors:  Eeva M Sommer; Hannah Dry; Darren Cross; Sylvie Guichard; Barry R Davies; Dario R Alessi
Journal:  Biochem J       Date:  2013-06-15       Impact factor: 3.857

7.  PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition.

Authors:  Pau Castel; Haley Ellis; Ruzica Bago; Eneda Toska; Pedram Razavi; F Javier Carmona; Srinivasaraghavan Kannan; Chandra S Verma; Maura Dickler; Sarat Chandarlapaty; Edi Brogi; Dario R Alessi; José Baselga; Maurizio Scaltriti
Journal:  Cancer Cell       Date:  2016-07-21       Impact factor: 31.743
  7 in total
  3 in total

1.  Androgen receptor inhibitor-induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer.

Authors:  Likun Li; Styliani Karanika; Guang Yang; Jiangxiang Wang; Sanghee Park; Bradley M Broom; Ganiraju C Manyam; Wenhui Wu; Yong Luo; Spyridon Basourakos; Jian H Song; Gary E Gallick; Theodoros Karantanos; Dimitrios Korentzelos; Abul Kalam Azad; Jeri Kim; Paul G Corn; Ana M Aparicio; Christopher J Logothetis; Patricia Troncoso; Timothy Heffernan; Carlo Toniatti; Hyun-Sung Lee; Ju-Seog Lee; Xuemei Zuo; Wenjun Chang; Jianhua Yin; Timothy C Thompson
Journal:  Sci Signal       Date:  2017-05-23       Impact factor: 8.192

2.  Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer.

Authors:  Hongtao Wang; Fang Huang; Zhe Zhang; Peng Wang; Yuan Luo; Hailiang Li; Na Li; Jian Wang; Jianguang Zhou; Yongan Wang; Shanhu Li
Journal:  Int J Biol Sci       Date:  2019-03-09       Impact factor: 6.580

3.  Neuroprotective Role of Akt in Hypoxia Adaptation in Andeans.

Authors:  Helen Zhao; Jonathan Lin; Gary Sieck; Gabriel G Haddad
Journal:  Front Neurosci       Date:  2021-01-15       Impact factor: 4.677
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.