Seung Hee Choi1, Chan Kyo Kim, Jung Jae Park, Byung Kwan Park. 1. From the *Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sunkyunkwan University School of Medicine, and †Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, Korea.
Abstract
OBJECTIVE: This study aimed to investigate blood oxygenation level-dependent magnetic resonance imaging (MRI) in assessing early therapeutic changes in cervical cancers to concurrent chemoradiotherapy (CCRT). METHODS: Fifteen consecutive patients with cervical cancer treated with CCRT were evaluated with blood oxygenation level-dependent MRI at 3 T. Magnetic resonance imaging examinations were performed before treatment (preTx), 1 week after treatment (postT1) and 4 weeks after treatment (postT2). At each time, the rate of spin dephasing (R2*) values were measured in tumor and in normal uterus. RESULTS: Tumor R2* increased from preTx to postT2 (P < 0.01). In pairwise comparisons of tumor R2*, postT2 was significantly higher than preTx or postT1 (P < 0.01), whereas postT1 was not significantly different from preTx (P > 0.05). A significant difference in R2* was found between the tumors and normal uterus at preTx (P = 0.001), postT1 (P < 0.001), and postT2 (P < 0.001). CONCLUSIONS: Blood oxygenation level-dependent MRI may demonstrate early therapeutic changes of cervical cancers to CCRT.
OBJECTIVE: This study aimed to investigate blood oxygenation level-dependent magnetic resonance imaging (MRI) in assessing early therapeutic changes in cervical cancers to concurrent chemoradiotherapy (CCRT). METHODS: Fifteen consecutive patients with cervical cancer treated with CCRT were evaluated with blood oxygenation level-dependent MRI at 3 T. Magnetic resonance imaging examinations were performed before treatment (preTx), 1 week after treatment (postT1) and 4 weeks after treatment (postT2). At each time, the rate of spin dephasing (R2*) values were measured in tumor and in normal uterus. RESULTS:Tumor R2* increased from preTx to postT2 (P < 0.01). In pairwise comparisons of tumor R2*, postT2 was significantly higher than preTx or postT1 (P < 0.01), whereas postT1 was not significantly different from preTx (P > 0.05). A significant difference in R2* was found between the tumors and normal uterus at preTx (P = 0.001), postT1 (P < 0.001), and postT2 (P < 0.001). CONCLUSIONS: Blood oxygenation level-dependent MRI may demonstrate early therapeutic changes of cervical cancers to CCRT.
Authors: Joseph Waller; Benjamin Onderdonk; Ann Flood; Harold Swartz; Jaffer Shah; Asghar Shah; Bulent Aydogan; Howard Halpern; Yasmin Hasan Journal: Br J Radiol Date: 2020-04-22 Impact factor: 3.039
Authors: Otto Glader; Elina Puljula; Johanna Jokioja; Maarit Karonen; Jari Sinkkonen; Jukka Hytönen Journal: Sci Rep Date: 2019-05-29 Impact factor: 4.379