Literature DB >> 27635038

The Role of MicroRNA and LncRNA-MicroRNA Interactions in Regulating Ischemic Heart Disease.

Na Li1, Murugavel Ponnusamy1, Meng-Peng Li1, Kun Wang1, Pei-Feng Li1.   

Abstract

Approximately 2% of the human genome consists of protein-coding regions. Therefore, the majority of transcripts are noncoding RNAs, such as microRNA (miRNA) and long noncoding RNAs (lncRNAs). In ischemic heart disease, the majority of miRNAs are repressors or destabilizers of target messenger RNAs. The lncRNAs are a second class of noncoding RNAs that have recently gained attention for their roles in heart disease and in regulating the functions of miRNA. In this review, we summarize the role of miRNA in pathological cardiac hypertrophy and myocardial infarction. In addition, we discuss the functional interactions of miRNA and lncRNA and its impact on these ischemic heart diseases.

Entities:  

Keywords:  lncRNA; microRNA; microRNA–lncRNA interaction; myocardial infarction; pathological cardiac hypertrophy

Year:  2016        PMID： 27635038     DOI： 10.1177/1074248416667600

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol Ther        ISSN： 1074-2484            Impact factor:   2.457


  14 in total

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3.  Knockdown of Long Non-Coding RNA AFAP1-AS1 Promoted Viability and Suppressed Death of Cardiomyocytes in Response to I/R In Vitro and In Vivo.

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5.  Long Noncoding RNA (lncRNA) n379519 Promotes Cardiac Fibrosis in Post-Infarct Myocardium by Targeting miR-30.

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6.  Expression profiles of long noncoding RNAs and mRNAs in peripheral blood mononuclear cells of patients with acute myocardial infarction.

Authors:  Pingsen Zhao; Heming Wu; Zhixiong Zhong; Qifeng Zhang; Wei Zhong; Bin Li; Cunren Li; Zhidong Liu; Min Yang
Journal:  Medicine (Baltimore)       Date:  2018-10       Impact factor: 1.817

7.  Downregulation of Long Noncoding RNA LINC00261 Attenuates Myocardial Infarction through the miR-522-3p/Trinucleotide Repeat-Containing Gene 6a (TNRC6A) Axis.

Authors:  Chaoxin Jiang; Qing Zhao; Chenlong Wang; Minyan Peng; Guoqing Hao; Zhifeng Liu; Wenjin Fu; Kewei Zhao
Journal:  Cardiovasc Ther       Date:  2021-06-18       Impact factor: 3.023

8.  Integrated analysis of coding genes and non-coding RNAs during hair follicle cycle of cashmere goat (Capra hircus).

Authors:  Shanhe Wang; Wei Ge; Zhixin Luo; Yang Guo; Beilei Jiao; Lei Qu; Zhiying Zhang; Xin Wang
Journal:  BMC Genomics       Date:  2017-10-11       Impact factor: 3.969

9.  LncRNA MEG3 targeting miR-424-5p via MAPK signaling pathway mediates neuronal apoptosis in ischemic stroke.

Authors:  Yanxiao Xiang; Yayun Zhang; Yanni Xia; Hua Zhao; Anchang Liu; Yuguo Chen
Journal:  Aging (Albany NY)       Date:  2020-02-16       Impact factor: 5.682

10.  LncRNA GUSBP5-AS promotes EPC migration and angiogenesis and deep vein thrombosis resolution by regulating FGF2 and MMP2/9 through the miR-223-3p/FOXO1/Akt pathway.

Authors:  Li-Li Sun; Feng-Rui Lei; Xu-Dong Jiang; Xiao-Long Du; Lun Xiao; Wen-Dong Li; Xiao-Qiang Li
Journal:  Aging (Albany NY)       Date:  2020-03-10       Impact factor: 5.682
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