Literature DB >> 27634936

Epidermal growth factor prevents oligomeric amyloid-β induced angiogenesis deficits in vitro.

Kevin P Koster1, Riya Thomas1, Alan W J Morris1, Leon M Tai2.   

Abstract

Cerebrovascular dysfunction is a critical component of Alzheimer's disease (AD) pathogenesis. Oligomeric amyloid-β42 (oAβ42) is considered a major contributor to AD progression. However, data are limited on the role of oAβ42 in brain endothelial cell vessel degeneration/angiogenesis, including the interaction with angiogenic mediators. Thus, the current study determined the effect of oAβ42 on angiogenesis in vitro, utilizing single brain endothelial cell cultures and triple cultures mimicking the microvascular unit (MVU: brain endothelial cells, astrocytes, and pericytes). oAβ42 dose-dependently reduced angiogenesis and induced vessel disruption. Critically, epidermal growth factor prevented oAβ42-induced deficits, implicating angiogenic pathways as potential therapeutics for AD.
© The Author(s) 2016.

Entities:  

Keywords:  Alzheimer’s; angiogenesis; blood–brain barrier; cerebrovascular disease; endothelium; pericytes

Mesh：

Substances：

Year:  2016        PMID： 27634936      PMCID： PMC5094316          DOI： 10.1177/0271678X16669956

Source DB:  PubMed          Journal:  J Cereb Blood Flow Metab        ISSN： 0271-678X            Impact factor:   6.200


  20 in total

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3.  Astrocytes and pericytes cooperatively maintain a capillary-like structure composed of endothelial cells on gel matrix.

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4.  Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.

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  12 in total

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4.  VEGF receptor-1 modulates amyloid β 1-42 oligomer-induced senescence in brain endothelial cells.

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5.  Epidermal growth factor prevents APOE4 and amyloid-beta-induced cognitive and cerebrovascular deficits in female mice.

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6.  Peripheral Inflammation, Apolipoprotein E4, and Amyloid-β Interact to Induce Cognitive and Cerebrovascular Dysfunction.

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7.  Epidermal growth factor prevents APOE4-induced cognitive and cerebrovascular deficits in female mice.

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Journal:  Heliyon       Date:  2017-06-07

8.  Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction.

Authors:  Steve Zaldua; Frederick C Damen; Rohan Pisharody; Riya Thomas; Kelly D Fan; Giri K Ekkurthi; Sarah B Scheinman; Sami Alahmadi; Felecia M Marottoli; Simon Alford; Kejia Cai; Leon M Tai
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10.  Alzheimer's amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis.

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