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Literature DB >> 27633575

Epigenetic regulation of peroxiredoxins: Implications in the pathogenesis of cancer.

Suet-Hui Ow¹, Pei-Jou Chua¹, Boon-Huat Bay¹.

Abstract

Peroxiredoxin I to VI (PRX I-VI), a family of highly conserved antioxidants, has been implicated in numerous diseases. There have been reports that PRXs are expressed aberrantly in a variety of tumors, implying that they could play an important role in carcinogenesis. Epigenetic mechanisms such as DNA methylation, histone modifications, and microRNAs have been reported to modulate expression of PRXs. In addition, the use of epigenetic regulators, such as histone deacetylases, has been demonstrated to restore PRX to normal levels, indicating that the reversible nature of epigenetics can be exploited for future treatments.

Entities: Disease Gene

Keywords: Peroxiredoxin; epigenetic regulation; microRNA

Mesh：

Substances：

Year: 2016 PMID： 27633575 PMCID： PMC5167117 DOI： 10.1177/1535370216669834

Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699

88 in total

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Journal: Biochem Biophys Res Commun Date: 2001-11-30 Impact factor: 3.575

Review 2. Functional significance of aberrantly expressed microRNAs in prostate cancer.

Authors: Yusuke Goto; Akira Kurozumi; Hideki Enokida; Tomohiko Ichikawa; Naohiko Seki
Journal: Int J Urol Date: 2015-01-20 Impact factor: 3.369

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Authors: Kay Ka-Wai Li; Jesse Chung-Sean Pang; Kin-Mang Lau; Liangfu Zhou; Ying Mao; Yin Wang; Wai-Sang Poon; Ho-Keung Ng
Journal: Brain Pathol Date: 2013-01-09 Impact factor: 6.508

Review 4. Redox regulation of cancer cell migration and invasion.

Authors: Lalchhandami Tochhawng; Shuo Deng; Shazib Pervaiz; Celestial T Yap
Journal: Mitochondrion Date: 2012-08-27 Impact factor: 4.160

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Journal: Br J Cancer Date: 2013-07-23 Impact factor: 7.640

Review 7. Current and upcoming approaches to exploit the reversibility of epigenetic mutations in breast cancer.

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Journal: Breast Cancer Res Date: 2014-07-29 Impact factor: 6.466

8. Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer.

Authors: Xin-Zhong Chang; Da-Qiang Li; Yi-Feng Hou; Jiong Wu; Jin-Song Lu; Gen-Hong Di; Wei Jin; Zhou-Luo Ou; Zhen-Zhou Shen; Zhi-Ming Shao
Journal: Breast Cancer Res Date: 2007 Impact factor: 6.466

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Authors: Wenjie Jiang; Jie Min; Xiaohui Sui; Yanyan Qian; Ying Liu; Zhaojian Liu; Haibin Zhou; Xi Li; Yaoqin Gong
Journal: Leuk Lymphoma Date: 2014-06-25

10. Profile of differentially expressed miRNAs in high-grade serous carcinoma and clear cell ovarian carcinoma, and the expression of miR-510 in ovarian carcinoma.

Authors: Xinchen Zhang; Gordon Guo; Guang Wang; Jinyao Zhao; Bo Wang; Xiaotang Yu; Yanfang Ding
Journal: Mol Med Rep Date: 2015-10-26 Impact factor: 2.952

4 in total