Literature DB >> 27632563

Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses.

Amber B Rico1, Aaron T Phillips2, Tony Schountz2, Donald L Jarvis3, Ronald B Tjalkens4, Ann M Powers5, Ken E Olson2.   

Abstract

Eastern, Venezuelan and western equine encephalitis viruses (EEEV, VEEV, and WEEV) are mosquito-borne viruses that cause substantial disease in humans and other vertebrates. Vaccines are limited and current treatment options have not proven successful. In this report, we vaccinated outbred mice with lipid-antigen-nucleic acid-complexes (LANACs) containing VEEV E1+WEEV E1 antigen and characterized protective efficacy against lethal EEEV, VEEV, and WEEV challenge. Vaccination resulted in complete protection against EEEV, VEEV, and WEEV in CD-1 mice. Measurements of bioluminescence and plaque reduction neutralization tests (PRNTs) indicate that LANAC VEEV E1+WEEV E1 vaccination is sterilizing against VEEV and WEEV challenge; whereas immunity to EEEV is not sterilizing. Passive transfer of rabbit VEEV E1+WEEV E1 immune serum to naive mice extended the mean time to death (MTD) of EEEV challenged mice and provided significant protection from lethal VEEV and WEEV challenge.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Alphavirus; Bioluminescence; Eastern equine encephalitis virus; In vivo imaging; Subunit vaccine; Togaviridae; Venezuelan equine encephalitis virus; Western equine encephalitis virus

Mesh：

Substances：

Year:  2016        PMID： 27632563      PMCID： PMC5884135          DOI： 10.1016/j.virol.2016.08.023

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  25 in total

1.  Subunit vaccine formulations based on recombinant envelope proteins of Chikungunya virus elicit balanced Th1/Th2 response and virus-neutralizing antibodies in mice.

Authors:  Mohsin Khan; Rekha Dhanwani; Putcha Venkata Lakshamana Rao; Manmohan Parida
Journal:  Virus Res       Date:  2012-05-17       Impact factor: 3.303

2.  Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection.

Authors:  Aaron T Phillips; Amber B Rico; Charles B Stauft; Sean L Hammond; Tawfik A Aboellail; Ronald B Tjalkens; Ken E Olson
Journal:  J Virol       Date:  2016-05-27       Impact factor: 5.103

3.  Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: eastern equine and western equine encephalitis.

Authors:  Ronald B Reisler; Paul H Gibbs; Denise K Danner; Ellen F Boudreau
Journal:  Vaccine       Date:  2012-09-29       Impact factor: 3.641

4.  Protection against pneumonic plague following oral immunization with a non-replicating vaccine.

Authors:  Abby Jones; Catharine Bosio; Angela Duffy; Andrew Goodyear; Martin Schriefer; Steven Dow
Journal:  Vaccine       Date:  2010-06-19       Impact factor: 3.641

5.  Evaluation of a Western Equine Encephalitis recombinant E1 protein for protective immunity and diagnostics.

Authors:  Dipankar Das; Sheryl L Gares; Les P Nagata; Mavanur R Suresh
Journal:  Antiviral Res       Date:  2004-11       Impact factor: 5.970

Review 6.  The alphaviruses: gene expression, replication, and evolution.

Authors:  J H Strauss; E G Strauss
Journal:  Microbiol Rev       Date:  1994-09

Review 7.  Encephalitic alphaviruses.

Authors:  Michele A Zacks; Slobodan Paessler
Journal:  Vet Microbiol       Date:  2009-08-28       Impact factor: 3.293

8.  A chimeric Sindbis-based vaccine protects cynomolgus macaques against a lethal aerosol challenge of eastern equine encephalitis virus.

Authors:  Chad J Roy; A Paige Adams; Eryu Wang; Grace Leal; Robert L Seymour; Satheesh K Sivasubramani; William Mega; Ilya Frolov; Peter J Didier; Scott C Weaver
Journal:  Vaccine       Date:  2013-01-16       Impact factor: 3.641

9.  Induction of protection against leishmaniasis in susceptible BALB/c mice using simple DOTAP cationic nanoliposomes containing soluble Leishmania antigen (SLA).

Authors:  Hengameh Firouzmand; Ali Badiee; Ali Khamesipour; Vahid Heravi Shargh; Seyedeh Hoda Alavizadeh; Azam Abbasi; Mahmoud Reza Jaafari
Journal:  Acta Trop       Date:  2013-08-02       Impact factor: 3.112

10.  Bioluminescent imaging and histopathologic characterization of WEEV neuroinvasion in outbred CD-1 mice.

Authors:  Aaron T Phillips; Charles B Stauft; Tawfik A Aboellail; Ann M Toth; Donald L Jarvis; Ann M Powers; Ken E Olson
Journal:  PLoS One       Date:  2013-01-02       Impact factor: 3.240
View more
  6 in total

1.  Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.

Authors:  Arthur S Kim; Natasha M Kafai; Emma S Winkler; Theron C Gilliland; Emily L Cottle; James T Earnest; Prashant N Jethva; Paulina Kaplonek; Aadit P Shah; Rachel H Fong; Edgar Davidson; Ryan J Malonis; Jose A Quiroz; Lauren E Williamson; Lo Vang; Matthias Mack; James E Crowe; Benjamin J Doranz; Jonathan R Lai; Galit Alter; Michael L Gross; William B Klimstra; Daved H Fremont; Michael S Diamond
Journal:  Cell       Date:  2021-08-19       Impact factor: 66.850

Review 2.  Current Understanding of the Molecular Basis of Venezuelan Equine Encephalitis Virus Pathogenesis and Vaccine Development.

Authors:  Anuj Sharma; Barbara Knollmann-Ritschel
Journal:  Viruses       Date:  2019-02-18       Impact factor: 5.048

3.  Approach to Strain Selection and the Propagation of Viral Stocks for Venezuelan Equine Encephalitis Virus Vaccine Efficacy Testing under the Animal Rule.

Authors:  Janice M Rusnak; Pamela J Glass; Scott C Weaver; Carol L Sabourin; Andrew M Glenn; William Klimstra; Christopher S Badorrek; Farooq Nasar; Lucy A Ward
Journal:  Viruses       Date:  2019-08-31       Impact factor: 5.048

4.  Antibodies for Venezuelan Equine Encephalitis Virus Protect Embryoid Bodies from Chikungunya Virus.

Authors:  Emily M Schultz; TyAnthony J Jones; Kelli L Barr
Journal:  Viruses       Date:  2020-02-27       Impact factor: 5.048

5.  Exposing cryptic epitopes on the Venezuelan equine encephalitis virus E1 glycoprotein prior to treatment with alphavirus cross-reactive monoclonal antibody allows blockage of replication early in infection.

Authors:  Amanda E Calvert; Susan L Bennett; Ann R Hunt; Rachel H Fong; Benjamin J Doranz; John T Roehrig; Carol D Blair
Journal:  Virology       Date:  2021-09-28       Impact factor: 3.616

6.  Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus.

Authors:  Crystal W Burke; Jeffrey W Froude; Sebastian Miethe; Birgit Hülseweh; Michael Hust; Pamela J Glass
Journal:  Viruses       Date:  2018-03-24       Impact factor: 5.048
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.