| Literature DB >> 27631880 |
Emily K Don1, Isabel Formella1, Andrew P Badrock1, Thomas E Hall2, Marco Morsch1, Elinor Hortle1, Alison Hogan1, Sharron Chow1, Serene S L Gwee1, Jack J Stoddart1, Garth Nicholson1,3, Roger Chung1, Nicholas J Cole1.
Abstract
Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration.Entities:
Keywords: Tol2 gateway; disease model; neurodegenerative disease; transgenesis
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Year: 2016 PMID： 27631880 DOI： 10.1089/zeb.2016.1321
Source DB: PubMed Journal: Zebrafish ISSN： 1545-8547 Impact factor: 1.985