Vikas Parshottam Bhakhar1, Vandana Sandip Shah2, Mohsin Jiva Ghanchi3, Sandesh Sachchidanand Gosavi4, Himanshu Mahesh Srivastava5, Nivedita Javahir Pachore6. 1. Senior Lecturer, Department of Oral Pathology, College of Dental Science , Bhavnagar, Gujarat, India . 2. Professor and Head, Department of Oral Pathology, K. M. Shah Dental College , Vadodara, Gujarat, India . 3. Professor and Head, Department of Oral Pathology, College of Dental Science , Bhavnagar, Gujarat, India . 4. Dean, College of Dental Science , Bhavnagar, Gujarat, India . 5. Post Graduate Student, Department of Oral Pathology, K. M. Shah Dental College , Vadodara, Gujarat, India . 6. Senior Lecturer, Department of Prosthodontics, College of Dental Science , Bhavnagar, Gujarat, India .
Abstract
INTRODUCTION: Odontogenic cysts viz Odontogenic Keratocyst (OKC), Dentigerous Cyst (DC) and Radicular Cyst (RC) occur commonly in the oral and maxillofacial region. Cytokeratin (CK) expression studies have been done to evaluate diagnostic accuracy, role in pathogenesis, elucidate behaviour and role in treatment protocols. However, variations have been reported in the expression of CK patterns in these odontogenic cysts, which could be due to the lack of standardization of laboratory techniques. The present study has tried to shed light on CK 18 and 19 expression in odontogenic cysts and offer the brief review of previous studies on these CK. AIM: The aim of the present study was to evaluate the intensity and expression patterns of CK 18 and 19 in OKCs, DCs and RCs. MATERIALS AND METHODS: A total of 60 cases, 20 each of OKC, DC and RC were confirmed histologically and evaluated for immunohistochemical expression pattern and intensity of CK 18 and 19. RESULTS: A focal and variable expression of CK 18 was observed in 25% of OKCs, 15% of DCs and 10% of RCs. CK 19 was expressed in 75% of OKCs and 100% in DCs as well as RCs. CONCLUSION: The intensity and expression of Cytokeratin 19 was more in all three cysts compared to Cytokeratin 18.
INTRODUCTION: Odontogenic cysts viz Odontogenic Keratocyst (OKC), Dentigerous Cyst (DC) and Radicular Cyst (RC) occur commonly in the oral and maxillofacial region. Cytokeratin (CK) expression studies have been done to evaluate diagnostic accuracy, role in pathogenesis, elucidate behaviour and role in treatment protocols. However, variations have been reported in the expression of CK patterns in these odontogenic cysts, which could be due to the lack of standardization of laboratory techniques. The present study has tried to shed light on CK 18 and 19 expression in odontogenic cysts and offer the brief review of previous studies on these CK. AIM: The aim of the present study was to evaluate the intensity and expression patterns of CK 18 and 19 in OKCs, DCs and RCs. MATERIALS AND METHODS: A total of 60 cases, 20 each of OKC, DC and RC were confirmed histologically and evaluated for immunohistochemical expression pattern and intensity of CK 18 and 19. RESULTS: A focal and variable expression of CK 18 was observed in 25% of OKCs, 15% of DCs and 10% of RCs. CK 19 was expressed in 75% of OKCs and 100% in DCs as well as RCs. CONCLUSION: The intensity and expression of Cytokeratin 19 was more in all three cysts compared to Cytokeratin 18.
Authors: C N V Akhila; G Sreenath; A Ravi Prakash; M Rajini Kanth; A Vikram Simha Reddy; S Naveen Kumar Journal: J Oral Maxillofac Pathol Date: 2021-05-14