Literature DB >> 27630923

Cortical Clefts and Cortical Bumps: A Continuous Spectrum.

Asthik Biswas1, Farha Furruqh1, Suresh Thirunavukarasu2, Ravichandran Vivekandan3.   

Abstract

Cortical 'clefts' (schizencephaly) and cortical 'bumps' (polymicrogyria) are malformations arising due to defects in postmigrational development of neurons. They are frequently encountered together, with schizencephalic clefts being lined by polymicrogyria. We present the case of an eight-year-old boy who presented with seizures. Imaging revealed closed lip schizencephaly, polymicrogyria and a deep 'incomplete' cleft lined by polymicrogyria not communicating with the lateral ventricle. We speculate that hypoperfusion or ischaemic cortical injury during neuronal development may lead to a spectrum of malformations ranging from polymicrogyria to incomplete cortical clefts to schizencephaly.

Entities:  

Keywords:  Brain; Development; Malformation; Polymicrogyria; Schizencephaly

Year:  2016        PMID： 27630923      PMCID： PMC5020188          DOI： 10.7860/JCDR/2016/20343.8179

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN： 0973-709X


  10 in total

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Authors:  A J Barkovich; R Hevner; R Guerrini
Journal:  AJNR Am J Neuroradiol       Date:  1999 Nov-Dec       Impact factor: 3.825

2.  Schizencephalies; a study of the congenital clefts in the cerebral mantle; clefts with hydrocephalus and lips separated.

Authors:  P I YAKOVLEV; R C WADSWORTH
Journal:  J Neuropathol Exp Neurol       Date:  1946-07       Impact factor: 3.685

Review 3.  A developmental and genetic classification for malformations of cortical development.

Authors:  A J Barkovich; R I Kuzniecky; G D Jackson; R Guerrini; W B Dobyns
Journal:  Neurology       Date:  2005-09-28       Impact factor: 9.910

Review 4.  Disorders of cortical formation: MR imaging features.

Authors:  A A K Abdel Razek; A Y Kandell; L G Elsorogy; A Elmongy; A A Basett
Journal:  AJNR Am J Neuroradiol       Date:  2008-08-07       Impact factor: 3.825

Review 5.  Schizencephaly: correlation of clinical findings with MR characteristics.

Authors:  A J Barkovich; B O Kjos
Journal:  AJNR Am J Neuroradiol       Date:  1992 Jan-Feb       Impact factor: 3.825

6.  Schizencephalies; a study of the congenital clefts in the cerebral mantle; clefts with fused lips.

Authors:  P I YAKOVLEV; R C WADSWORTH
Journal:  J Neuropathol Exp Neurol       Date:  1946-04       Impact factor: 3.685

Review 7.  Disorders of neuronal migration.

Authors:  P G Barth
Journal:  Can J Neurol Sci       Date:  1987-02       Impact factor: 2.104

8.  Clinical and imaging heterogeneity of polymicrogyria: a study of 328 patients.

Authors:  Richard J Leventer; Anna Jansen; Daniela T Pilz; Neil Stoodley; Carla Marini; Francois Dubeau; Jodie Malone; L Anne Mitchell; Simone Mandelstam; Ingrid E Scheffer; Samuel F Berkovic; Frederick Andermann; Eva Andermann; Renzo Guerrini; William B Dobyns
Journal:  Brain       Date:  2010-04-19       Impact factor: 13.501

Review 9.  Neuronal migration and contact guidance in the primate telencephalon.

Authors:  P Rakic
Journal:  Postgrad Med J       Date:  1978       Impact factor: 2.401

Review 10.  A developmental and genetic classification for malformations of cortical development: update 2012.

Authors:  A James Barkovich; Renzo Guerrini; Ruben I Kuzniecky; Graeme D Jackson; William B Dobyns
Journal:  Brain       Date:  2012-03-16       Impact factor: 13.501
  10 in total
  1 in total

1.  Brain Lesions in Children with Unilateral Spastic Cerebral Palsy.

Authors:  Feriha Hadzagic-Catibusic; Edin Avdagic; Smail Zubcevic; Sajra Uzicanin
Journal:  Med Arch       Date:  2017-02-05
  1 in total

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