Yousef Rasmi1, Javad Zeynalzadeh2, Alireza Shirpoor3, Mirhossein Seyedmohammadzad4, Reza Hajhosseini5. 1. Professor, Cellular and Molecular Research Center, Urmia University of Medical Sciences , Urmia, Iran; Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran . 2. Student, Department of Biology, Faculty of Sciences, Payam-e Noor University , Tehran, Iran . 3. Associate Professor, Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences , Urmia, Iran . 4. Associate Professor, Department of Cardiology, Faculty of Medicine, Urmia University of Medical Sciences , Urmia, Iran . 5. Associate Professor, Department of Biology, Faculty of Sciences, Payam-e Noor University , Tehran, Iran .
Abstract
INTRODUCTION: Chronic inflammation caused by Helicobacter pylori (H.pylori) infection has a pathogenic role in Cardiac Syndrome X (CSX). In addition, it has shown that bacterial infection may affect blood lipids. AIM: To assess if H.pylori affects the level of lipid profile in CSX. MATERIALS AND METHODS: Eighty-eight CSX patients and 97 healthy controls were enrolled. The Total Cholesterol (TC), Triglyceride (TG), Lipoprotein A (LP{A}), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Apoprotein A1 (APOA1), and Apoprotein B (APOB) was estimated colorimetrically. In addition, the presence of IgG antibody to H.pylori was tested in plasma samples by using enzyme linked immunosorbent assay method. RESULTS: TC, LP{A}, LDL, APOA1 and APOB levels in CSX group were significantly higher than those of the control group (p<0.05). But, these parameters in H.pylori positive and H.pylori negative, among CSX and control groups were not significant. CONCLUSION: Increased plasma level of lipid profile and H.pylori infection were associated with CSX; it seems that plasma lipid disorders have a significant role in the development of CSX.
INTRODUCTION:Chronic inflammation caused by Helicobacter pylori (H.pylori) infection has a pathogenic role in Cardiac Syndrome X (CSX). In addition, it has shown that bacterial infection may affect blood lipids. AIM: To assess if H.pylori affects the level of lipid profile in CSX. MATERIALS AND METHODS: Eighty-eight CSXpatients and 97 healthy controls were enrolled. The Total Cholesterol (TC), Triglyceride (TG), Lipoprotein A (LP{A}), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), Apoprotein A1 (APOA1), and Apoprotein B (APOB) was estimated colorimetrically. In addition, the presence of IgG antibody to H.pylori was tested in plasma samples by using enzyme linked immunosorbent assay method. RESULTS:TC, LP{A}, LDL, APOA1 and APOB levels in CSX group were significantly higher than those of the control group (p<0.05). But, these parameters in H.pylori positive and H.pylori negative, among CSX and control groups were not significant. CONCLUSION: Increased plasma level of lipid profile and H.pyloriinfection were associated with CSX; it seems that plasma lipid disorders have a significant role in the development of CSX.
Authors: A Hoffmeister; D Rothenbacher; G Bode; K Persson; W März; M A Nauck; H Brenner; V Hombach; W Koenig Journal: Arterioscler Thromb Vasc Biol Date: 2001-03 Impact factor: 8.311
Authors: Dong-Hoon Kim; Byoung Kwan Son; Kyueng-Whan Min; Sang Kuk Han; Ji Ung Na; Pil Cho Choi; Hack-Lyoung Kim; Mi Jung Kwon; Young Ha Oh; Woon Yong Jung; Ji-Yong Moon; Sangmo Hong; Ki-Wook Oh; Young Seo Kim Journal: J Clin Med Date: 2020-06-14 Impact factor: 4.241