Yuki Matsuoka1, Yohei Yurugi1, Yuzo Takagi2, Makoto Wakahara1, Yasuaki Kubouchi2, Tomohiko Sakabe3, Tomohiro Haruki2, Kunio Araki2, Yuji Taniguchi2, Hiroshige Nakamura3, Yoshihisa Umekita4. 1. Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Tottori, Japan Division of General Thoracic Surgery, Department of Surgery, Faculty of Medicine, Tottori University, Tottori, Japan. 2. Division of General Thoracic Surgery, Department of Surgery, Faculty of Medicine, Tottori University, Tottori, Japan. 3. Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Tottori, Japan. 4. Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Tottori, Japan yume@med.tottori-u.ac.jp.
Abstract
BACKGROUND/AIM: We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. PATIENTS AND METHODS: A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and the European Respiratory Society classification. The presence of solid (S+) or micropapillary component (MP+) was defined when the component constituted ≥1% of the entire tumor. The impact of these components on disease-free (DFS) and disease-specific (DSS) survival was analyzed. RESULTS: Thirty (26.1%) cases with S+ and 27 (23.5%) with MP+ were identified, and multivariate analysis indicated that S+ status significantly reduced the duration of DFS and DSS. In 86 patients of acinar- and papillary-predominant subgroups, S+ and/or MP+ had the most significant effect on DFS and DSS by multivariate analysis. CONCLUSION: S+ and/or MP+ status predict worse prognosis in patients with acinar- and papillary-predominant lung adenocarcinoma. Copyright
BACKGROUND/AIM: We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. PATIENTS AND METHODS: A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and the European Respiratory Society classification. The presence of solid (S+) or micropapillary component (MP+) was defined when the component constituted ≥1% of the entire tumor. The impact of these components on disease-free (DFS) and disease-specific (DSS) survival was analyzed. RESULTS: Thirty (26.1%) cases with S+ and 27 (23.5%) with MP+ were identified, and multivariate analysis indicated that S+ status significantly reduced the duration of DFS and DSS. In 86 patients of acinar- and papillary-predominant subgroups, S+ and/or MP+ had the most significant effect on DFS and DSS by multivariate analysis. CONCLUSION: S+ and/or MP+ status predict worse prognosis in patients with acinar- and papillary-predominant lung adenocarcinoma. Copyright
Authors: Tamás Zombori; Tibor Nyári; László Tiszlavicz; Regina Pálföldi; Edit Csada; Tibor Géczi; Aurél Ottlakán; Balázs Pécsy; Gábor Cserni; József Furák Journal: Virchows Arch Date: 2018-04-02 Impact factor: 4.064
Authors: Sun Ha Choi; Ji Yun Jeong; Shin Yup Lee; Kyung Min Shin; Shin Young Jeong; Tae-In Park; Young Woo Do; Eung Bae Lee; Yangki Seok; Won Kee Lee; Ji Eun Park; Sunji Park; Yong Hoon Lee; Hyewon Seo; Seung Soo Yoo; Jaehee Lee; Seung-Ick Cha; Chang Ho Kim; Jae Yong Park Journal: Thorac Cancer Date: 2020-11-24 Impact factor: 3.223