Francesca DE Felice1, Lavinia Grapulin2, Daniela Musio2, Jenny Pomponi2, Cinzia DI Felice3, Anna Paola Iori4, Alice Bertaina5, Vincenzo Tombolini6. 1. Department of Radiotherapy, Thrombosis Center, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy fradefelice@hotmail.it. 2. Department of Radiotherapy, Thrombosis Center, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. 3. Department of Medical Physics, Thrombosis Center, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. 4. Department of Cellular Biotechnologies and Hematology, Thrombosis Center, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. 5. Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. 6. Department of Radiotherapy, Thrombosis Center, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy Spencer-Lorillard Foundation, Rome, Italy.
Abstract
BACKGROUND: The aim of this study was to evaluate treatment-related toxicity and clinical outcomes of total body irradiation (TBI) in patients with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: We performed a retrospective review of all patients with ALL who underwent TBI-based conditioning regimen at our Institution between 2000 and 2012. RESULTS: A total of 211 patients were included. The median follow-up was 40 months. The 5-year overall survival and disease-free survival were 64.7% and 62.8%, respectively. The 5-year overall survival rate for the 163 children was 67.6% (95% confidence interval=55-77%). Disease status at time of transplant did not improve disease-free survival. Gastrointestinal acute toxicity was the most common early side-effect (19.9%). Acute graft-versus-host disease was reported in 31 patients (14.7%). Main late toxicities were cataract induction (12.8%) and growth, gonadal and endocrine effects (36%). CONCLUSION: TBI-based conditioning regimen led to a high survival rate with remarkably low radiation-related toxicity, suggesting that TBI provides a feasible therapeutic option in patients with ALL. Copyright
BACKGROUND: The aim of this study was to evaluate treatment-related toxicity and clinical outcomes of total body irradiation (TBI) in patients with acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: We performed a retrospective review of all patients with ALL who underwent TBI-based conditioning regimen at our Institution between 2000 and 2012. RESULTS: A total of 211 patients were included. The median follow-up was 40 months. The 5-year overall survival and disease-free survival were 64.7% and 62.8%, respectively. The 5-year overall survival rate for the 163 children was 67.6% (95% confidence interval=55-77%). Disease status at time of transplant did not improve disease-free survival. Gastrointestinal acute toxicity was the most common early side-effect (19.9%). Acute graft-versus-host disease was reported in 31 patients (14.7%). Main late toxicities were cataract induction (12.8%) and growth, gonadal and endocrine effects (36%). CONCLUSION: TBI-based conditioning regimen led to a high survival rate with remarkably low radiation-related toxicity, suggesting that TBI provides a feasible therapeutic option in patients with ALL. Copyright
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