Gabriel Liberale1, Sophie Vankerckhove2, Maria Gomez Galdon3, Denis Larsimont3, Bissan Ahmed2, Fikri Bouazza4, Michel Moreau5, Issam El Nakadi4, Vincent Donckier4, Pierre Bourgeois2. 1. Department of Surgical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium Gabriel.liberale@bordet.be. 2. Department of Nuclear Medicine and Clinic-Unit of Lymphology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium. 3. Department of Pathology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium. 4. Department of Surgical Oncology, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium. 5. Data Centre and Department of Statistics, Jules Bordet Institute, Free University of Brussels, Brussels, Belgium.
Abstract
BACKGROUND/AIM: Nodal staging is used in colorectal cancer (CRC) to determine which patients should receive adjuvant chemotherapy. The aim of this study was to evaluate the role of indocyanine green fluorescence imaging (ICG-FI) in sentinel lymph node (SLN) detection compared to the standard technique. MATERIALS AND METHODS: Twenty patients with CRC admitted for elective colectomy were included (NCT01995591). Ex vivo SLN detection was performed using patent blue (PB) and free ICG injected around the tumor. RESULTS: Identification rates were 95% (19/20) for both techniques. Sensitivity was 43% for PB and 57% for ICG. Correlation between the techniques was 83%. FI was more sensitive in patients with body mass index (BMI) >25 kg/m(2) Serial section analysis did not allow for up-staging of patients. CONCLUSION: The use of ICG-FI is superior to the blue dye technique in patients with a BMI >25 kg/m(2) However, the sensitivity of ICG-FI in SLN detection remains low, with a high rate of false-negative results. Copyright
BACKGROUND/AIM: Nodal staging is used in colorectal cancer (CRC) to determine which patients should receive adjuvant chemotherapy. The aim of this study was to evaluate the role of indocyanine green fluorescence imaging (ICG-FI) in sentinel lymph node (SLN) detection compared to the standard technique. MATERIALS AND METHODS: Twenty patients with CRC admitted for elective colectomy were included (NCT01995591). Ex vivo SLN detection was performed using patent blue (PB) and free ICG injected around the tumor. RESULTS: Identification rates were 95% (19/20) for both techniques. Sensitivity was 43% for PB and 57% for ICG. Correlation between the techniques was 83%. FI was more sensitive in patients with body mass index (BMI) >25 kg/m(2) Serial section analysis did not allow for up-staging of patients. CONCLUSION: The use of ICG-FI is superior to the blue dye technique in patients with a BMI >25 kg/m(2) However, the sensitivity of ICG-FI in SLN detection remains low, with a high rate of false-negative results. Copyright
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