Gulsah Kaya Aksoy1,2, Mustafa Koyun3, Bahar Akkaya4, Elif Comak3, Atilla Gemici3, Sema Akman3. 1. Department of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey. gkayaaksoy@gmail.com. 2. Department of Pediatric Nephrology, Akdeniz University Medical Faculty, 07070, Antalya, Turkey. gkayaaksoy@gmail.com. 3. Department of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey. 4. Department of Pathology, Akdeniz University, School of Medicine, Antalya, Turkey.
Abstract
Drug-related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen-year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood urea nitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2. The patient whom pathological signs of renal biopsy sections revealed interstitial mononuclear cell and eosinophilic infiltration was diagnosed with acute tubulointerstitial nephritis. CONCLUSION: Isotretinoin is a vitamin A-derived agent which is commonly used in the treatment of acne and may cause drug-related acute tubulointerstitial nephritis. What is Known: •Drug-related acute tubulointerstitial nephritis (ATIN) is one of the most common causes of childhood acute renal failures. What is New: •Isotretinoin may cause drug-related acute tubulointerstitial nephritis.
Drug-related acute tubulointerstitial nephritis is one of the most common causes of childhood acute renal failures which originate from kidneys. Sixteen-year old male patient with the history of isotretinoin use for the last 3 months was admitted with acute renal failure. Renal function parameters were measured as follows: blood ureanitrogen 21 mg/dL, serum creatinine 1.68 mg/dL, cystatin C 1.15 mg/L, and estimated glomerular filtration rate based on cystatin C 56.5 mL/min/1.73 m2. The patient whom pathological signs of renal biopsy sections revealed interstitial mononuclear cell and eosinophilic infiltration was diagnosed with acute tubulointerstitial nephritis. CONCLUSION:Isotretinoin is a vitamin A-derived agent which is commonly used in the treatment of acne and may cause drug-related acute tubulointerstitial nephritis. What is Known: •Drug-related acute tubulointerstitial nephritis (ATIN) is one of the most common causes of childhood acute renal failures. What is New: •Isotretinoin may cause drug-related acute tubulointerstitial nephritis.
Authors: Folasade F Fayiga; Sophia C Reyes-Hadsall; Ludonir C Sebastiany; Sergey Arutyunyan; Alan Wong; Ana M Duarte Journal: Skin Appendage Disord Date: 2021-07-28