BACKGROUND: Heart failure (HF) progression and its complications represent major emergent concerns in hypertrophic cardiomyopathy (HCM). We investigated the possible adjunctive role of cardiopulmonary exercise testing (CPET) in predicting HF-related events. An exercise-derived risk model, theHYPertrophicExercise-derivedRiskHF(HYPERHF), has been developed. METHODS AND RESULTS: A multicenter cohort of 620 consecutive HCM outpatients was recruited and followed (2007 to 2015). The endpoint was death from HF, cardiac transplantation, NYHA III-IV class progression, severe functional deterioration leading to hospitalization for septal reduction, and hospitalization for HF worsening. During a median follow-up of 3.8 years (25-75th centile: 2.3-5.3 years), 84 patients reached the endpoint. Peak circulatory power (peak oxygen consumption * peak systolic blood pressure), ventilatory efficiency and left atrial diameter were independently associated with the endpoint and, accordingly, integrated into the HYPERHFmodel (C index: 0.849; best cutoff value equal to 15%). CONCLUSIONS: CPET is useful in the evaluation of HCM patients. In this context, the HYPERHFscore might allow early identification of those patients at high risk of HF progression and its complications. (Circ J 2016; 80: 2204-2211).
BACKGROUND:Heart failure (HF) progression and its complications represent major emergent concerns in hypertrophic cardiomyopathy (HCM). We investigated the possible adjunctive role of cardiopulmonary exercise testing (CPET) in predicting HF-related events. An exercise-derived risk model, theHYPertrophicExercise-derivedRiskHF(HYPERHF), has been developed. METHODS AND RESULTS: A multicenter cohort of 620 consecutive HCM outpatients was recruited and followed (2007 to 2015). The endpoint was death from HF, cardiac transplantation, NYHA III-IV class progression, severe functional deterioration leading to hospitalization for septal reduction, and hospitalization for HF worsening. During a median follow-up of 3.8 years (25-75th centile: 2.3-5.3 years), 84 patients reached the endpoint. Peak circulatory power (peak oxygen consumption * peak systolic blood pressure), ventilatory efficiency and left atrial diameter were independently associated with the endpoint and, accordingly, integrated into the HYPERHFmodel (C index: 0.849; best cutoff value equal to 15%). CONCLUSIONS: CPET is useful in the evaluation of HCM patients. In this context, the HYPERHFscore might allow early identification of those patients at high risk of HF progression and its complications. (Circ J 2016; 80: 2204-2211).
Authors: Robert Przybylski; Ilana R Fischer; Kimberlee Gauvreau; Mark E Alexander; Keri M Shafer; Steven D Colan; Christa Miliaresis; Jonathan Rhodes Journal: Pediatr Cardiol Date: 2022-01-20 Impact factor: 1.655
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Authors: Elisabetta Salvioni; Ugo Corrà; Massimo Piepoli; Sara Rovai; Michele Correale; Stefania Paolillo; Mario Pasquali; Damiano Magrì; Giuseppe Vitale; Laura Fusini; Massimo Mapelli; Carlo Vignati; Rocco Lagioia; Rosa Raimondo; Gianfranco Sinagra; Federico Boggio; Lorenzo Cangiano; Giovanna Gallo; Alessandra Magini; Mauro Contini; Pietro Palermo; Anna Apostolo; Beatrice Pezzuto; Alice Bonomi; Angela B Scardovi; Pasquale Perrone Filardi; Giuseppe Limongelli; Marco Metra; Domenico Scrutinio; Michele Emdin; Lucrezia Piccioli; Carlo Lombardi; Gaia Cattadori; Gianfranco Parati; Sergio Caravita; Federica Re; Mariantonietta Cicoira; Maria Frigerio; Francesco Clemenza; Maurizio Bussotti; Elisa Battaia; Marco Guazzi; Francesco Bandera; Roberto Badagliacca; Andrea Di Lenarda; Giuseppe Pacileo; Claudio Passino; Susanna Sciomer; Giuseppe Ambrosio; Piergiuseppe Agostoni Journal: ESC Heart Fail Date: 2020-01-01