Semra Acer1, Gökhan Pekel1, Vural Küçükatay2, Aysun Karabulut3, Ramazan Yağcı1, Ebru Nevin Çetin1, Şahika Pınar Akyer4, Barbaros Şahin5. 1. Department of Ophthalmology, Pamukkale University, Denizli, Turkey. 2. Department of Physiology, Pamukkale University, Denizli, Turkey. 3. Department of Gynecology and Obstetrics, Pamukkale University, Denizli, Turkey. 4. Department of Anatomy, Pamukkale University, Denizli, Turkey. 5. Experimental Animals Unit, Pamukkale University, Denizli, Turkey.
Abstract
PURPOSE: To evaluate lenticular oxidative stress in rat menopausal models. METHODS: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Group 1). From the rats that underwent oophorectomy, 10 formed the menopause control group (Group 2), 10 were administered a daily injection of methylprednisolone until the end of the study (Group 3), and the remaining 10 rats were administered intraperitoneal streptozocin to induce diabetes mellitus (Group 4). Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurements of the crystalline lenses were analyzed. RESULTS: The mean OSI was the lowest in group 1 and highest in group 4. Nevertheless, the difference between the groups was not statistically significant in terms of OSI (p >0.05). The mean TOS values were similar between the groups (p >0.05), whereas the mean TAC of group 1 was significantly higher than that of the other groups (p <0.001). CONCLUSIONS: Our results indicate that menopause may not promote cataract formation.
PURPOSE: To evaluate lenticular oxidative stress in rat menopausal models. METHODS: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Group 1). From the rats that underwent oophorectomy, 10 formed the menopause control group (Group 2), 10 were administered a daily injection of methylprednisolone until the end of the study (Group 3), and the remaining 10 rats were administered intraperitoneal streptozocin to induce diabetes mellitus (Group 4). Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurements of the crystalline lenses were analyzed. RESULTS: The mean OSI was the lowest in group 1 and highest in group 4. Nevertheless, the difference between the groups was not statistically significant in terms of OSI (p >0.05). The mean TOS values were similar between the groups (p >0.05), whereas the mean TAC of group 1 was significantly higher than that of the other groups (p <0.001). CONCLUSIONS: Our results indicate that menopause may not promote cataract formation.
Authors: Bo Lu; Ian T Christensen; Li-Wei Ma; Xin-Ling Wang; Ling-Feng Jiang; Chun-Xia Wang; Li Feng; Jin-Song Zhang; Qi-Chang Yan Journal: Mol Med Rep Date: 2018-01-25 Impact factor: 2.952