Literature DB >> 27624395

Molecular pathways driving disease-specific alterations of intestinal epithelial cells.

Rocío López-Posadas1, Markus F Neurath1, Imke Atreya2.   

Abstract

Due to the fact that chronic inflammation as well as tumorigenesis in the gut is crucially impacted by the fate of intestinal epithelial cells, our article provides a comprehensive overview of the composition, function, regulation and homeostasis of the gut epithelium. In particular, we focus on those aspects which were found to be altered in the context of inflammatory bowel diseases or colorectal cancer and also discuss potential molecular targets for a disease-specific therapeutic intervention.

Entities:  

Keywords:  Colitis-associated cancer; Colorectal cancer; Epithelial integrity; Inflammatory bowel diseases; Intestinal epithelial cells

Mesh：

Year:  2016        PMID： 27624395     DOI： 10.1007/s00018-016-2363-2

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  336 in total

Review 1.  Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium.

Authors:  Claudia Günther; Helmut Neumann; Markus F Neurath; Christoph Becker
Journal:  Gut       Date:  2012-06-11       Impact factor: 23.059

Review 2.  Regulation of apoptosis during homeostasis and disease in the intestinal epithelium.

Authors:  Karen L Edelblum; Fang Yan; Toshimitsu Yamaoka; D Brent Polk
Journal:  Inflamm Bowel Dis       Date:  2006-05       Impact factor: 5.325

3.  Clustering of increased small intestinal permeability in families with Crohn's disease.

Authors:  M Peeters; B Geypens; D Claus; H Nevens; Y Ghoos; G Verbeke; F Baert; S Vermeire; R Vlietinck; P Rutgeerts
Journal:  Gastroenterology       Date:  1997-09       Impact factor: 22.682

4.  Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

Authors:  Maria Van der Sluis; Barbara A E De Koning; Adrianus C J M De Bruijn; Anna Velcich; Jules P P Meijerink; Johannes B Van Goudoever; Hans A Büller; Jan Dekker; Isabelle Van Seuningen; Ingrid B Renes; Alexandra W C Einerhand
Journal:  Gastroenterology       Date:  2006-07       Impact factor: 22.682

5.  TNF-α and soluble forms of TNF receptors 1 and 2 in the serum of patients with Crohn's disease and ulcerative colitis.

Authors:  Danuta Owczarek; Dorota Cibor; Mikołaj K Głowacki; Andrzej Cieśla; Paweł Mach
Journal:  Pol Arch Med Wewn       Date:  2012-11-18

6.  Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease.

Authors:  Stephanie A Blair; Sunanda V Kane; Daniel R Clayburgh; Jerrold R Turner
Journal:  Lab Invest       Date:  2006-02       Impact factor: 5.662

7.  Possible role of mycobacteria in inflammatory bowel disease. II. Mycobacterial antibodies in Crohn's disease.

Authors:  W R Thayer; J A Coutu; R J Chiodini; H J Van Kruiningen; R S Merkal
Journal:  Dig Dis Sci       Date:  1984-12       Impact factor: 3.199

8.  Epithelial NEMO links innate immunity to chronic intestinal inflammation.

Authors:  Arianna Nenci; Christoph Becker; Andy Wullaert; Ralph Gareus; Geert van Loo; Silvio Danese; Marion Huth; Alexei Nikolaev; Clemens Neufert; Blair Madison; Deborah Gumucio; Markus F Neurath; Manolis Pasparakis
Journal:  Nature       Date:  2007-03-14       Impact factor: 49.962

9.  Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease.

Authors:  Peter Suenaert; Veerle Bulteel; Liesbeth Lemmens; Maja Noman; Benny Geypens; Gert Van Assche; Karel Geboes; Jan L Ceuppens; Paul Rutgeerts
Journal:  Am J Gastroenterol       Date:  2002-08       Impact factor: 10.864

10.  STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon.

Authors:  Andrew V Nguyen; Yuan-Yuan Wu; Qiang Liu; Donghai Wang; Stephanie Nguyen; Ricky Loh; Joey Pang; Kenneth Friedman; Amos Orlofsky; Leonard Augenlicht; Jeffrey W Pollard; Elaine Y Lin
Journal:  Neoplasia       Date:  2013-09       Impact factor: 5.715
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  8 in total

1.  Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity.

Authors:  Stephanie Oertel; Klaus Scholich; Andreas Weigert; Dominique Thomas; Julia Schmetzer; Sandra Trautmann; Marthe-Susanna Wegner; Heinfried H Radeke; Natalie Filmann; Bernhard Brüne; Gerd Geisslinger; Irmgard Tegeder; Sabine Grösch
Journal:  Cell Mol Life Sci       Date:  2017-04-12       Impact factor: 9.261

2.  Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing.

Authors:  Veronika Butin-Israeli; Triet M Bui; Hannah L Wiesolek; Lorraine Mascarenhas; Joseph J Lee; Lindsey C Mehl; Kaitlyn R Knutson; Stephen A Adam; Robert D Goldman; Arthur Beyder; Lisa Wiesmuller; Stephen B Hanauer; Ronen Sumagin
Journal:  J Clin Invest       Date:  2019-01-14       Impact factor: 14.808

3.  Hyperglycemia minimally alters primary self-renewing human colonic epithelial cells while TNFα-promotes severe intestinal epithelial dysfunction.

Authors:  Johanna S Dutton; Samuel S Hinman; Raehyun Kim; Peter J Attayek; Mallory Maurer; Christopher S Sims; Nancy L Allbritton
Journal:  Integr Biol (Camb)       Date:  2021-06-15       Impact factor: 2.192

Review 4.  Innate Lymphoid Cells as Regulators of Epithelial Integrity: Therapeutic Implications for Inflammatory Bowel Diseases.

Authors:  Anja Schulz-Kuhnt; Markus F Neurath; Stefan Wirtz; Imke Atreya
Journal:  Front Med (Lausanne)       Date:  2021-03-30

Review 5.  Apoptosis Exerts a Vital Role in the Treatment of Colitis-Associated Cancer by Herbal Medicine.

Authors:  Ruimin Tian; Xianfeng Liu; Yanqin Luo; Shengnan Jiang; Hong Liu; Fengming You; Chuan Zheng; Jiasi Wu
Journal:  Front Pharmacol       Date:  2020-04-28       Impact factor: 5.810

6.  ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.

Authors:  Bartolomeus J Meijer; Francesca P Giugliano; Bart Baan; Jonathan H M van der Meer; Sander Meisner; Manon van Roest; Pim J Koelink; Ruben J de Boer; Nic Jones; Wolfgang Breitwieser; Nicole N van der Wel; Manon E Wildenberg; Gijs R van den Brink; Jarom Heijmans; Vanesa Muncan
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2020-01-17

Review 7.  Multifaceted Impacts of Periodontal Pathogens in Disorders of the Intestinal Barrier.

Authors:  Yingman Liu; Wenxuan Huang; Jiaqi Wang; Jiaojiao Ma; Manman Zhang; Xiaoying Lu; Jie Liu; Yurong Kou
Journal:  Front Immunol       Date:  2021-07-27       Impact factor: 7.561

8.  Editorial: Loss of Epithelial Barrier Integrity in Inflammatory Diseases: Cellular Mediators and Therapeutic Targets.

Authors:  Carl Weidinger; Susanne M Krug; Caroline Voskens; Alexander R Moschen; Imke Atreya
Journal:  Front Med (Lausanne)       Date:  2021-12-09
  8 in total

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