Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Protein evolution on rugged landscapes.

Literature DB >> 2762321

Protein evolution on rugged landscapes.

Abstract

We analyze a mathematical model of protein evolution in which the evolutionary process is viewed as hill-climbing on a random fitness landscape. In studying the structure of such landscapes, we note that a large number of local optima exist, and we calculate the time and number of mutational changes until a protein gets trapped at a local optimum. Such a hill-climbing process may underlie the evolution of antibody molecules by somatic hypermutation.

Mesh：

Substances：
Proteins

Year: 1989 PMID： 2762321 PMCID： PMC297803 DOI： 10.1073/pnas.86.16.6191

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

16 in total

1. Somatic evolution of variable region structures during an immune response.

Authors: L Wysocki; T Manser; M L Gefter
Journal: Proc Natl Acad Sci U S A Date: 1986-03 Impact factor: 11.205

Review 2. Mutation drift and repertoire shift in the maturation of the immune response.

Authors: C Berek; C Milstein
Journal: Immunol Rev Date: 1987-04 Impact factor: 12.988

3. Natural selection and the concept of a protein space.

Authors: J M Smith
Journal: Nature Date: 1970-02-07 Impact factor: 49.962

4. Variable region framework differences result in decreased or increased affinity of variant anti-digoxin antibodies.

Authors: D J Panka; M Mudgett-Hunter; D R Parks; L L Peterson; L A Herzenberg; E Haber; M N Margolies
Journal: Proc Natl Acad Sci U S A Date: 1988-05 Impact factor: 11.205

5. Somatic variants of murine immunoglobulin lambda light chains.

Authors: A L Bothwell; M Paskind; M Reth; T Imanishi-Kari; K Rajewsky; D Baltimore
Journal: Nature Date: 1982-07-22 Impact factor: 49.962

6. A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.

Authors: S Crews; J Griffin; H Huang; K Calame; L Hood
Journal: Cell Date: 1981-07 Impact factor: 41.582

7. Single amino acid substitution altering antigen-binding specificity.

Authors: S Rudikoff; A M Giusti; W D Cook; M D Scharff
Journal: Proc Natl Acad Sci U S A Date: 1982-03 Impact factor: 11.205

8. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

Authors: D McKean; K Huppi; M Bell; L Staudt; W Gerhard; M Weigert
Journal: Proc Natl Acad Sci U S A Date: 1984-05 Impact factor: 11.205

9. Somatic mutation and clonal expansion of B cells in an antigen-driven immune response.

Authors: F Sablitzky; G Wildner; K Rajewsky
Journal: EMBO J Date: 1985-02 Impact factor: 11.598

10. Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin.

Authors: S H Clarke; K Huppi; D Ruezinsky; L Staudt; W Gerhard; M Weigert
Journal: J Exp Med Date: 1985-04-01 Impact factor: 14.307

31 in total

1. Real time forecasting of near-future evolution.

Authors: Philip J Gerrish; Paul D Sniegowski
Journal: J R Soc Interface Date: 2012-04-18 Impact factor: 4.118

2. Mutational effects and population dynamics during viral adaptation challenge current models.

Authors: Craig R Miller; Paul Joyce; Holly A Wichman
Journal: Genetics Date: 2010-11-01 Impact factor: 4.562

3. Breaking evolutionary constraint with a tradeoff ratchet.

Authors: Marjon G J de Vos; Alexandre Dawid; Vanda Sunderlikova; Sander J Tans
Journal: Proc Natl Acad Sci U S A Date: 2015-11-13 Impact factor: 11.205

4. Comparing folding codes in simple heteropolymer models of protein evolutionary landscape: robustness of the superfunnel paradigm.

Authors: Richard Wroe; Erich Bornberg-Bauer; Hue Sun Chan
Journal: Biophys J Date: 2004-10-22 Impact factor: 4.033