Akihito Takeuchi1, Takashi Yorifuji2, Kyohei Takahashi3, Makoto Nakamura4, Misao Kageyama4, Toshihide Kubo3, Tatsuya Ogino5, Katsuhiro Kobayashi6, Hiroyuki Doi7. 1. Department of Neonatology, Okayama Medical Center, National Hospital Organization, Okayama, Japan. Electronic address: gmd18025@s.okayama-u.ac.jp. 2. Department of Human Ecology, Okayama University Graduate School of Environmental and Life Science, Okayama, Japan. 3. Department of Pediatrics, Okayama Medical Center, National Hospital Organization, Okayama, Japan. 4. Department of Neonatology, Okayama Medical Center, National Hospital Organization, Okayama, Japan. 5. Department of Children Studies, Faculty of Children Studies, Chugokugakuen University, Okayama, Japan. 6. Department of Child Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. 7. Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Abstract
BACKGROUND: Small for gestational age (SGA) birth is linked with neurological deficits among children at pre-school age, but the evidence is still limited on whether such deficits are still observable at school age. We investigated the association between SGA birth and behavioral development at school age among full-term infants. METHODS: We analyzed data from a large, Japanese, nationwide, population-based longitudinal survey that started in 2001. We restricted the study participants to children born at 37-41weeks of gestation with information on birth weight and behavioral outcomes at 8years of age (n=33,795). Behavioral outcomes including three attentional problems and four aggressive behaviors queried at 8years of age by survey questions were used as outcome indicators. We then used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for the associations between SGA birth and each outcome, adjusting for potential infant- and parent-related confounding factors. RESULTS: Among full-term children, SGA children were more likely to interrupt people (OR 1.10, 95% CI 1.01, 1.20), unable to wait his/her turn (OR 1.17, 95% CI 1.00, 1.38), and destroy toys and/or books (OR 1.15, 95% CI 1.00, 1.31). CONCLUSIONS: This is the largest study ever conducted on this issue. SGA birth is negatively associated with some attentional problems and aggressive behavior at school age among full-term children. Appropriate long-term developmental follow-up and support may be needed for full-term SGA infants.
BACKGROUND: Small for gestational age (SGA) birth is linked with neurological deficits among children at pre-school age, but the evidence is still limited on whether such deficits are still observable at school age. We investigated the association between SGA birth and behavioral development at school age among full-term infants. METHODS: We analyzed data from a large, Japanese, nationwide, population-based longitudinal survey that started in 2001. We restricted the study participants to children born at 37-41weeks of gestation with information on birth weight and behavioral outcomes at 8years of age (n=33,795). Behavioral outcomes including three attentional problems and four aggressive behaviors queried at 8years of age by survey questions were used as outcome indicators. We then used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for the associations between SGA birth and each outcome, adjusting for potential infant- and parent-related confounding factors. RESULTS: Among full-term children, SGA children were more likely to interrupt people (OR 1.10, 95% CI 1.01, 1.20), unable to wait his/her turn (OR 1.17, 95% CI 1.00, 1.38), and destroy toys and/or books (OR 1.15, 95% CI 1.00, 1.31). CONCLUSIONS: This is the largest study ever conducted on this issue. SGA birth is negatively associated with some attentional problems and aggressive behavior at school age among full-term children. Appropriate long-term developmental follow-up and support may be needed for full-term SGA infants.
Authors: Man Zhang; Marufu Martin Gazimbi; Zhong Chen; Bin Zhang; Yanru Chen; Yizhen Yu; Jie Tang Journal: BMJ Open Date: 2020-01-02 Impact factor: 2.692
Authors: Cathrin Vano Mehl; Ingrid Marie Husby Hollund; Johanne Marie Iversen; Stian Lydersen; Paul Jarle Mork; Eero Kajantie; Kari Anne I Evensen Journal: Health Qual Life Outcomes Date: 2022-03-24 Impact factor: 3.186