Literature DB >> 27622329

Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities.

Daichi Inoue1, Omar Abdel-Wahab2.   

Abstract

In this issue of Cancer Cell, Obeng et al. identify the consequences of expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis. The knockin mouse model described represents a valuable tool to dissect the effects of SF3B1 mutations on transformation, splicing, and less well-characterized functions of SF3B1.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27622329      PMCID： PMC5569387          DOI： 10.1016/j.ccell.2016.08.013

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.

Authors:  Kyoichi Isono; Yoko Mizutani-Koseki; Toshihisa Komori; Marion S Schmidt-Zachmann; Haruhiko Koseki
Journal:  Genes Dev       Date:  2005-03-01       Impact factor: 11.361

2.  SF3B1 association with chromatin determines splicing outcomes.

Authors:  Nir Kfir; Galit Lev-Maor; Ohad Glaich; Adi Alajem; Arnab Datta; Siu K Sze; Eran Meshorer; Gil Ast
Journal:  Cell Rep       Date:  2015-04-16       Impact factor: 9.423

3.  SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes.

Authors:  Valeria Visconte; Heesun J Rogers; Jarnail Singh; John Barnard; Manoj Bupathi; Fabiola Traina; James McMahon; Hideki Makishima; Hadrian Szpurka; Anna Jankowska; Andres Jerez; Mikkael A Sekeres; Yogen Saunthararajah; Anjali S Advani; Edward Copelan; Haruhiko Koseki; Kyoichi Isono; Richard A Padgett; Sami Osman; Kazunori Koide; Christine O'Keefe; Jaroslaw P Maciejewski; Ramon V Tiu
Journal:  Blood       Date:  2012-07-23       Impact factor: 22.113

4.  Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo.

Authors:  Cara Lunn Shirai; James N Ley; Brian S White; Sanghyun Kim; Justin Tibbitts; Jin Shao; Matthew Ndonwi; Brian Wadugu; Eric J Duncavage; Theresa Okeyo-Owuor; Tuoen Liu; Malachi Griffith; Sean McGrath; Vincent Magrini; Robert S Fulton; Catrina Fronick; Michelle O'Laughlin; Timothy A Graubert; Matthew J Walter
Journal:  Cancer Cell       Date:  2015-05-11       Impact factor: 31.743

5.  SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing.

Authors:  Yukiko Komeno; Yi-Jou Huang; Jinsong Qiu; Leo Lin; YiJun Xu; Yu Zhou; Liang Chen; Dora D Monterroza; Hairi Li; Russell C DeKelver; Ming Yan; Xiang-Dong Fu; Dong-Er Zhang
Journal:  Mol Cell Biol       Date:  2015-06-29       Impact factor: 4.272

6.  Physiologic Expression of Sf3b1(K700E) Causes Impaired Erythropoiesis, Aberrant Splicing, and Sensitivity to Therapeutic Spliceosome Modulation.

Authors:  Esther A Obeng; Ryan J Chappell; Michael Seiler; Michelle C Chen; Dean R Campagna; Paul J Schmidt; Rebekka K Schneider; Allegra M Lord; Lili Wang; Rutendo G Gambe; Marie E McConkey; Abdullah M Ali; Azra Raza; Lihua Yu; Silvia Buonamici; Peter G Smith; Ann Mullally; Catherine J Wu; Mark D Fleming; Benjamin L Ebert
Journal:  Cancer Cell       Date:  2016-09-12       Impact factor: 31.743

7.  Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia.

Authors:  Changshan Wang; Goro Sashida; Atsunori Saraya; Reiko Ishiga; Shuhei Koide; Motohiko Oshima; Kyoichi Isono; Haruhiko Koseki; Atsushi Iwama
Journal:  Blood       Date:  2014-04-15       Impact factor: 22.113

8.  Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.

Authors:  M Matsunawa; R Yamamoto; M Sanada; A Sato-Otsubo; Y Shiozawa; K Yoshida; M Otsu; Y Shiraishi; S Miyano; K Isono; H Koseki; H Nakauchi; S Ogawa
Journal:  Leukemia       Date:  2014-02-18       Impact factor: 11.528

9.  SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition.

Authors:  Eunhee Kim; Janine O Ilagan; Yang Liang; Gerrit M Daubner; Stanley C-W Lee; Aravind Ramakrishnan; Yue Li; Young Rock Chung; Jean-Baptiste Micol; Michele E Murphy; Hana Cho; Min-Kyung Kim; Ahmad S Zebari; Shlomzion Aumann; Christopher Y Park; Silvia Buonamici; Peter G Smith; H Joachim Deeg; Camille Lobry; Iannis Aifantis; Yorgo Modis; Frederic H-T Allain; Stephanie Halene; Robert K Bradley; Omar Abdel-Wahab
Journal:  Cancer Cell       Date:  2015-05-11       Impact factor: 31.743

10.  Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins.

Authors:  Stanley Chun-Wei Lee; Heidi Dvinge; Eunhee Kim; Hana Cho; Jean-Baptiste Micol; Young Rock Chung; Benjamin H Durham; Akihide Yoshimi; Young Joon Kim; Michael Thomas; Camille Lobry; Chun-Wei Chen; Alessandro Pastore; Justin Taylor; Xujun Wang; Andrei Krivtsov; Scott A Armstrong; James Palacino; Silvia Buonamici; Peter G Smith; Robert K Bradley; Omar Abdel-Wahab
Journal:  Nat Med       Date:  2016-05-02       Impact factor: 53.440
  10 in total
  13 in total

Review 1.  RNA Splicing and Disease: Animal Models to Therapies.

Authors:  Matías Montes; Brianne L Sanford; Daniel F Comiskey; Dawn S Chandler
Journal:  Trends Genet       Date:  2018-11-19       Impact factor: 11.639

2.  Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia.

Authors:  Yalu Zhou; Cuijuan Han; Eric Wang; Adam H Lorch; Valentina Serafin; Byoung-Kyu Cho; Blanca T Gutierrez Diaz; Julien Calvo; Celestia Fang; Alireza Khodadadi-Jamayran; Tommaso Tabaglio; Christian Marier; Anna Kuchmiy; Limin Sun; George Yacu; Szymon K Filip; Qi Jin; Yoh-Hei Takahashi; David R Amici; Emily J Rendleman; Radhika Rawat; Silvia Bresolin; Maddalena Paganin; Cheng Zhang; Hu Li; Irawati Kandela; Yuliya Politanska; Hiam Abdala-Valencia; Marc L Mendillo; Ping Zhu; Bruno Palhais; Pieter Van Vlierberghe; Tom Taghon; Iannis Aifantis; Young Ah Goo; Ernesto Guccione; Adriana Heguy; Aristotelis Tsirigos; Keng Boon Wee; Rama K Mishra; Francoise Pflumio; Benedetta Accordi; Giuseppe Basso; Panagiotis Ntziachristos
Journal:  Cancer Discov       Date:  2020-05-22       Impact factor: 39.397

Review 3.  Roles and mechanisms of alternative splicing in cancer - implications for care.

Authors:  Sophie C Bonnal; Irene López-Oreja; Juan Valcárcel
Journal:  Nat Rev Clin Oncol       Date:  2020-04-17       Impact factor: 66.675

4.  Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1.

Authors:  Shuiling Jin; Hairui Su; Ngoc-Tung Tran; Jing Song; Sydney S Lu; Ying Li; Suming Huang; Omar Abdel-Wahab; Yanyan Liu; Xinyang Zhao
Journal:  PLoS One       Date:  2017-05-18       Impact factor: 3.240

5.  Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1.

Authors:  Dennis Liang Fei; Tao Zhen; Benjamin Durham; John Ferrarone; Tuo Zhang; Lisa Garrett; Akihide Yoshimi; Omar Abdel-Wahab; Robert K Bradley; Paul Liu; Harold Varmus
Journal:  Proc Natl Acad Sci U S A       Date:  2018-10-15       Impact factor: 11.205

6.  Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN with RS-T) complicated by hyperleukocytosis and gene analysis in relation to leukocytosis.

Authors:  Yumi Aoyama; Kazuko Sakai; Taiichi Kodaka; Hiroko Tsunemine; Kazuto Nishio; Tomoo Itoh; Daichi Inoue; Takayuki Takahashi
Journal:  J Clin Exp Hematop       Date:  2019-02-07

7.  Recurrent hotspot SF3B1 mutations at codon 625 in vulvovaginal mucosal melanoma identified in a study of 27 Australian mucosal melanomas.

Authors:  Camelia Quek; Robert V Rawson; Peter M Ferguson; Ping Shang; Ines Silva; Robyn P M Saw; Kerwin Shannon; John F Thompson; Nicholas K Hayward; Georgina V Long; Graham J Mann; Richard A Scolyer; James S Wilmott
Journal:  Oncotarget       Date:  2019-01-29

Review 8.  Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies.

Authors:  Justin Taylor; Stanley C Lee
Journal:  Genes Chromosomes Cancer       Date:  2019-09-03       Impact factor: 5.006

Review 9.  The functional mechanisms of mutations in myelodysplastic syndrome.

Authors:  Yasunobu Nagata; Jaroslaw P Maciejewski
Journal:  Leukemia       Date:  2019-10-31       Impact factor: 11.528

10.  A cell-based splicing reporter system to identify regulators of cis-splicing between adjacent genes.

Authors:  Katarzyna Chwalenia; Fujun Qin; Sandeep Singh; Hui Li
Journal:  Nucleic Acids Res       Date:  2019-02-28       Impact factor: 16.971
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