Jorge Alejandro Alegría-Torres1,2, Marion Velázquez-Villafaña1, Juan Manuel López-Gutiérrez3, Marcela M Chagoyán-Martínez4, Diana O Rocha-Amador1, Rogelio Costilla-Salazar3, Lizeth García-Torres2. 1. 1 División de Ciencias Naturales y Exactas, Departamento de Farmacia, Campus Guanajuato, Universidad de Guanajuato , Guanajuato, México . 2. 2 Laboratorio de Investigación Molecular en Nutrición, LIMON, Universidad del Centro de México UCEM , San Luis Potosí, México . 3. 3 División de Ciencias de la Vida, Departamento de Ciencias Ambientales, Universidad de Guanajuato , Guanajuato, México . 4. 4 Unidad Interdisciplinaria de Ingeniería, Campus Guanajuato, Instituto Politécnico Nacional , Silao, Guanajuato, México .
Abstract
AIM: The purpose of this study was to determine if there is a correlation between telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) in children. METHODS: Leukocyte TL and mtDNAcn were measured by real-time PCR in 98 Mexican children 6-12 years of age from Salamanca, México. RESULTS: A positive association was found between TL and mtDNAcn after a natural log transformation (Pearson correlation r = 0.72; p < 0.0001). No correlation between age and body mass index (BMI) biomarkers was found, and no differences according to sex were observed. After adjustment for these variables, a linear regression model showed an association between TL and mtDNAcn (β = 0.739, 95% confidence interval 0.594; 0.885, p < 0.0001). CONCLUSIONS: A strong positive correlation between TL and mtDNAcn was found in the study population; age, sex, and BMI seemed to have no effect on this correlation.
AIM: The purpose of this study was to determine if there is a correlation between telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) in children. METHODS: Leukocyte TL and mtDNAcn were measured by real-time PCR in 98 Mexican children 6-12 years of age from Salamanca, México. RESULTS: A positive association was found between TL and mtDNAcn after a natural log transformation (Pearson correlation r = 0.72; p < 0.0001). No correlation between age and body mass index (BMI) biomarkers was found, and no differences according to sex were observed. After adjustment for these variables, a linear regression model showed an association between TL and mtDNAcn (β = 0.739, 95% confidence interval 0.594; 0.885, p < 0.0001). CONCLUSIONS: A strong positive correlation between TL and mtDNAcn was found in the study population; age, sex, and BMI seemed to have no effect on this correlation.
Entities:
Keywords:
Mexican children; mitochondrial DNA copy number; telomere length
Authors: Dóra Melicher; Anett Illés; Éva Pállinger; Árpád Ferenc Kovács; Levente Littvay; Ádám Domonkos Tárnoki; Dávid László Tárnoki; András Bikov; Mária Judit Molnár; Edit Irén Buzás; András Falus Journal: Cell Mol Life Sci Date: 2017-12-30 Impact factor: 9.261
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