Literature DB >> 27622069

Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer.

Amir A Al-Khami1, Paulo C Rodriguez2, Augusto C Ochoa3.   

Abstract

MDSC undergo metabolic reprogramming in the tumor resulting in an increased fatty acid β oxidation that supports their immunosuppressive functions. Fatty acid oxidation inhibitors, used to treat coronary disease, significantly delayed tumor growth and had a significantly increased antitumor effect when combined with adoptive cell therapy or low dose chemotherapy.

Entities:  

Keywords:  Cancer; Immunometabolism; MDSC

Year:  2016        PMID： 27622069      PMCID： PMC5007951          DOI： 10.1080/2162402X.2016.1200771

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  On respiratory impairment in cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-08-10       Impact factor: 47.728

2.  MDSC: a new player in HIV immunopathogenesis.

Authors:  Bernard J C Macatangay; Alan L Landay; Charles R Rinaldo
Journal:  AIDS       Date:  2012-07-31       Impact factor: 4.177

Review 3.  Fueling immunity: insights into metabolism and lymphocyte function.

Authors:  Erika L Pearce; Maya C Poffenberger; Chih-Hao Chang; Russell G Jones
Journal:  Science       Date:  2013-10-11       Impact factor: 47.728

4.  Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.

Authors:  David G DeNardo; Donal J Brennan; Elton Rexhepaj; Brian Ruffell; Stephen L Shiao; Stephen F Madden; William M Gallagher; Nikhil Wadhwani; Scott D Keil; Sharfaa A Junaid; Hope S Rugo; E Shelley Hwang; Karin Jirström; Brian L West; Lisa M Coussens
Journal:  Cancer Discov       Date:  2011-06-01       Impact factor: 39.397

5.  Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies.

Authors:  Fokhrul Hossain; Amir A Al-Khami; Dorota Wyczechowska; Claudia Hernandez; Liqin Zheng; Krzystoff Reiss; Luis Del Valle; Jimena Trillo-Tinoco; Tomasz Maj; Weiping Zou; Paulo C Rodriguez; Augusto C Ochoa
Journal:  Cancer Immunol Res       Date:  2015-05-29       Impact factor: 11.151

6.  Lipid accumulation and dendritic cell dysfunction in cancer.

Authors:  Donna L Herber; Wei Cao; Yulia Nefedova; Sergey V Novitskiy; Srinivas Nagaraj; Vladimir A Tyurin; Alex Corzo; Hyun-Il Cho; Esteban Celis; Brianna Lennox; Stella C Knight; Tapan Padhya; Thomas V McCaffrey; Judith C McCaffrey; Scott Antonia; Mayer Fishman; Robert L Ferris; Valerian E Kagan; Dmitry I Gabrilovich
Journal:  Nat Med       Date:  2010-07-11       Impact factor: 53.440

Review 7.  Metabolic pathways in immune cell activation and quiescence.

Authors:  Erika L Pearce; Edward J Pearce
Journal:  Immunity       Date:  2013-04-18       Impact factor: 31.745

Review 8.  Tumor cell metabolism: cancer's Achilles' heel.

Authors:  Guido Kroemer; Jacques Pouyssegur
Journal:  Cancer Cell       Date:  2008-06       Impact factor: 31.743

Review 9.  Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives.

Authors:  Paulo C Rodríguez; Augusto C Ochoa
Journal:  Immunol Rev       Date:  2008-04       Impact factor: 12.988

Review 10.  Myeloid-derived suppressor cells as regulators of the immune system.

Authors:  Dmitry I Gabrilovich; Srinivas Nagaraj
Journal:  Nat Rev Immunol       Date:  2009-03       Impact factor: 53.106
  10 in total
  30 in total

Review 1.  Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy.

Authors:  Jackie E Bader; Kelsey Voss; Jeffrey C Rathmell
Journal:  Mol Cell       Date:  2020-06-18       Impact factor: 17.970

Review 2.  Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting.

Authors:  Vijay Kumar
Journal:  Inflammation       Date:  2019-06       Impact factor: 4.092

Review 3.  Energy metabolic pathways control the fate and function of myeloid immune cells.

Authors:  Amir A Al-Khami; Paulo C Rodriguez; Augusto C Ochoa
Journal:  J Leukoc Biol       Date:  2017-05-17       Impact factor: 4.962

Review 4.  The promise and peril of targeting cell metabolism for cancer therapy.

Authors:  Jonathan M Weiss
Journal:  Cancer Immunol Immunother       Date:  2019-11-28       Impact factor: 6.968

Review 5.  The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates.

Authors:  Eslam Mohamed; Amir A Al-Khami; Paulo C Rodriguez
Journal:  Cell Mol Immunol       Date:  2018-03-22       Impact factor: 11.530

6.  Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.

Authors:  A A Al-Khami; M A Ghonim; L Del Valle; S V Ibba; L Zheng; K Pyakurel; S C Okpechi; J Garay; D Wyczechowska; M D Sanchez-Pino; P C Rodriguez; A H Boulares; A C Ochoa
Journal:  Clin Exp Allergy       Date:  2017-07-05       Impact factor: 5.018

Review 7.  Role of purines in regulation of metabolic reprogramming.

Authors:  Zhenwei Tang; Wenrui Ye; Haotian Chen; Xinwei Kuang; Jia Guo; Minmin Xiang; Cong Peng; Xiang Chen; Hong Liu
Journal:  Purinergic Signal       Date:  2019-09-06       Impact factor: 3.765

8.  Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells.

Authors:  Amir A Al-Khami; Liqin Zheng; Luis Del Valle; Fokhrul Hossain; Dorota Wyczechowska; Jovanny Zabaleta; Maria D Sanchez; Matthew J Dean; Paulo C Rodriguez; Augusto C Ochoa
Journal:  Oncoimmunology       Date:  2017-06-30       Impact factor: 8.110

Review 9.  Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy.

Authors:  Chunmei Fan; Shanshan Zhang; Zhaojian Gong; Xiayu Li; Bo Xiang; Hao Deng; Ming Zhou; Guiyuan Li; Yong Li; Wei Xiong; Zhaoyang Zeng; Xiaoling Li
Journal:  Sci China Life Sci       Date:  2020-08-17       Impact factor: 6.038

Review 10.  Metabolomics Monitoring of Treatment Response to Brain Tumor Immunotherapy.

Authors:  Farhad Dastmalchi; Loic P Deleyrolle; Aida Karachi; Duane A Mitchell; Maryam Rahman
Journal:  Front Oncol       Date:  2021-06-03       Impact factor: 6.244
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