Literature DB >> 27622017

MHC-multimer guided isolation of neoepitopes specific T cells as a potent-personalized cancer treatment strategy.

Roni Bareli1, Cyrille J Cohen1.   

Abstract

Analysis of genomic data from patient tumors provides valuable information as to potential T-cell targets such as neoepitopes. We developed an approach to characterize, isolate and utilize neoantigens-specific T cells using MHC/peptide tetramers from fresh tumor digests and peripheral blood. This bears important implications for the implementation of T cell-based immunotherapy.

Entities:  

Keywords:  Immunotherapy; MHC multimers; T-cells; TCR; neoantigens; tumor immunology

Year:  2016        PMID： 27622017      PMCID： PMC5006892          DOI： 10.1080/2162402X.2016.1159370

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Generation of peptide-MHC class I complexes through UV-mediated ligand exchange.

Authors:  Boris Rodenko; Mireille Toebes; Sine Reker Hadrup; Wim J E van Esch; Annemieke M Molenaar; Ton N M Schumacher; Huib Ovaa
Journal:  Nat Protoc       Date:  2006       Impact factor: 13.491

Review 2.  T-cell epitope prediction methods: an overview.

Authors:  Dattatraya V Desai; Urmila Kulkarni-Kale
Journal:  Methods Mol Biol       Date:  2014

3.  Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes.

Authors:  Cyrille J Cohen; Jared J Gartner; Miryam Horovitz-Fried; Katerina Shamalov; Kasia Trebska-McGowan; Valery V Bliskovsky; Maria R Parkhurst; Chen Ankri; Todd D Prickett; Jessica S Crystal; Yong F Li; Mona El-Gamil; Steven A Rosenberg; Paul F Robbins
Journal:  J Clin Invest       Date:  2015-09-21       Impact factor: 14.808

4.  Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.

Authors:  Eric Tran; Simon Turcotte; Alena Gros; Paul F Robbins; Yong-Chen Lu; Mark E Dudley; John R Wunderlich; Robert P Somerville; Katherine Hogan; Christian S Hinrichs; Maria R Parkhurst; James C Yang; Steven A Rosenberg
Journal:  Science       Date:  2014-05-09       Impact factor: 47.728

5.  Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer.

Authors:  Naiyer A Rizvi; Matthew D Hellmann; Alexandra Snyder; Pia Kvistborg; Vladimir Makarov; Jonathan J Havel; William Lee; Jianda Yuan; Phillip Wong; Teresa S Ho; Martin L Miller; Natasha Rekhtman; Andre L Moreira; Fawzia Ibrahim; Cameron Bruggeman; Billel Gasmi; Roberta Zappasodi; Yuka Maeda; Chris Sander; Edward B Garon; Taha Merghoub; Jedd D Wolchok; Ton N Schumacher; Timothy A Chan
Journal:  Science       Date:  2015-03-12       Impact factor: 47.728

6.  Targeting human melanoma neoantigens by T cell receptor gene therapy.

Authors:  Matthias Leisegang; Thomas Kammertoens; Wolfgang Uckert; Thomas Blankenstein
Journal:  J Clin Invest       Date:  2016-01-25       Impact factor: 14.808

Review 7.  Neoantigens in cancer immunotherapy.

Authors:  Ton N Schumacher; Robert D Schreiber
Journal:  Science       Date:  2015-04-03       Impact factor: 47.728

8.  Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.

Authors:  Matthew M Gubin; Xiuli Zhang; Heiko Schuster; Etienne Caron; Jeffrey P Ward; Takuro Noguchi; Yulia Ivanova; Jasreet Hundal; Cora D Arthur; Willem-Jan Krebber; Gwenn E Mulder; Mireille Toebes; Matthew D Vesely; Samuel S K Lam; Alan J Korman; James P Allison; Gordon J Freeman; Arlene H Sharpe; Erika L Pearce; Ton N Schumacher; Ruedi Aebersold; Hans-Georg Rammensee; Cornelis J M Melief; Elaine R Mardis; William E Gillanders; Maxim N Artyomov; Robert D Schreiber
Journal:  Nature       Date:  2014-11-27       Impact factor: 49.962

9.  Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells.

Authors:  Paul F Robbins; Yong-Chen Lu; Mona El-Gamil; Yong F Li; Colin Gross; Jared Gartner; Jimmy C Lin; Jamie K Teer; Paul Cliften; Eric Tycksen; Yardena Samuels; Steven A Rosenberg
Journal:  Nat Med       Date:  2013-05-05       Impact factor: 53.440

10.  Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens.

Authors:  Shelly Kalaora; Eilon Barnea; Efrat Merhavi-Shoham; Nouar Qutob; Jamie K Teer; Nilly Shimony; Jacob Schachter; Steven A Rosenberg; Michal J Besser; Arie Admon; Yardena Samuels
Journal:  Oncotarget       Date:  2016-02-02
  10 in total
  2 in total

Review 1.  Neoantigen Specific T Cells Derived From T Cell-Derived Induced Pluripotent Stem Cells for the Treatment of Hepatocellular Carcinoma: Potential and Challenges.

Authors:  Fei Lu; Xiao-Jing-Nan Ma; Wei-Lin Jin; Yang Luo; Xun Li
Journal:  Front Immunol       Date:  2021-05-13       Impact factor: 7.561

2.  Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides.

Authors:  Hanan Besser; Sharon Yunger; Efrat Merhavi-Shoham; Cyrille J Cohen; Yoram Louzoun
Journal:  J Immunother Cancer       Date:  2019-05-22       Impact factor: 13.751
  2 in total

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