Alexander Koch1, Ralf Weiskirchen2, Sebastian Ludwig1, Lukas Buendgens1, Jan Bruensing1, Eray Yagmur3, Christer Baeck1, Ulf Herbers1, Christian Trautwein1, Frank Tacke4. 1. Department of Medicine III, RWTH-University Hospital Aachen, Aachen, Germany. 2. Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH-University Hospital Aachen, Aachen, Germany. 3. Medical Care Center, Dr Stein and Colleagues, Mönchengladbach, Germany. 4. Department of Medicine III, RWTH-University Hospital Aachen, Aachen, Germany. Electronic address: frank.tacke@gmx.net.
Abstract
PURPOSE: Sclerostin is a negative regulator of bone metabolism and associated with chronic morbidities. We investigated circulating sclerostin in critically ill patients. METHODS: A total of 264 patients (170 with sepsis) were studied prospectively upon admission to the medical intensive care unit (ICU) and on day 7. Patients' survival was followed for up to 3 years. RESULTS: Sclerostin serum levels were significantly elevated in critically ill patients at ICU admission compared with 99 healthy controls. Unlike in healthy controls, sclerostin did not depend on sex or age of ICU patients. Sclerostin was associated with disease severity, independent of the presence of sepsis. Sclerostin levels increased during the first week of treatment at the ICU but were not a predictor of mortality. Sclerostin was elevated in patients with preexisting chronic kidney disease or liver cirrhosis, but was not related to diabetes, obesity, or cardiovascular disease. Circulating sclerostin in ICU patients correlated with biomarkers reflecting renal, hepatic and cardiac dysfunction, and biomarkers reflecting bone metabolism. CONCLUSION: Serum sclerostin concentrations are significantly elevated in critically ill patients, linked to renal or hepatic organ failure, and associated with bone resorption markers, supporting its value as a potential tool for the assessment of ICU-related metabolic bone disease.
PURPOSE:Sclerostin is a negative regulator of bone metabolism and associated with chronic morbidities. We investigated circulating sclerostin in critically illpatients. METHODS: A total of 264 patients (170 with sepsis) were studied prospectively upon admission to the medical intensive care unit (ICU) and on day 7. Patients' survival was followed for up to 3 years. RESULTS:Sclerostin serum levels were significantly elevated in critically illpatients at ICU admission compared with 99 healthy controls. Unlike in healthy controls, sclerostin did not depend on sex or age of ICU patients. Sclerostin was associated with disease severity, independent of the presence of sepsis. Sclerostin levels increased during the first week of treatment at the ICU but were not a predictor of mortality. Sclerostin was elevated in patients with preexisting chronic kidney disease or liver cirrhosis, but was not related to diabetes, obesity, or cardiovascular disease. Circulating sclerostin in ICU patients correlated with biomarkers reflecting renal, hepatic and cardiac dysfunction, and biomarkers reflecting bone metabolism. CONCLUSION: Serum sclerostin concentrations are significantly elevated in critically illpatients, linked to renal or hepatic organ failure, and associated with bone resorption markers, supporting its value as a potential tool for the assessment of ICU-related metabolic bone disease.
Authors: Alexander Koch; Eray Yagmur; Alexander Hoss; Lukas Buendgens; Ulf Herbers; Ralf Weiskirchen; Ger H Koek; Christian Trautwein; Frank Tacke Journal: J Clin Lab Anal Date: 2018-07-05 Impact factor: 2.352
Authors: Thor Ueland; Elisabeth Astrup; Kari Otterdal; Tove Lekva; Jeshina Janardhanan; John A J Prakash; Kurien Thomas; Annika E Michelsen; Pål Aukrust; George M Varghese; Jan K Damås Journal: PLoS Negl Trop Dis Date: 2021-04-29