Yan Guo1, Xue-Jing Yue2, He-Hua Li3, Zhi-Xiu Song3, Hai-Qing Yan3, Ping Zhang3, Yong-Kun Gui3, Li Chang3, Tong Li4. 1. Department of Neurology, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China. 2. Clinical Skills Training Center, Xinxiang Medical University, Xinxiang, Henan, China. 3. Department of Neurology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China. 4. Department of Neurology, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China. Electronic address: litong0833@126.com.
Abstract
BACKGROUND: A systematic review assessing the association between overweight and obesity in young adulthood and stroke risk is lacking. Therefore, we conducted a meta-analysis to evaluate the association between overweight and obesity in young adulthood and stroke risk. METHODS: We systematically searched PubMed and Embase databases for related studies of human subjects in the English language. Two investigators independently selected original studies in a 2-step process. Fixed- and random-effects models were used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs). Subgroup analyses were also performed. RESULTS: Eight studies met the inclusion criteria. The pooled adjusted RR of stroke was 1.36 (95% CI: 1.28-1.44) for overweight in young adulthood and 1.81 (95% CI: 1.45-2.25) for obesity in young adulthood. In subgroup analyses, overweight and obesity in young adulthood increased the risk of stroke in most groups, except for the group of stroke subtype. For ischemic stroke, the adjusted RR was 1.40 (95% CI: 1.24-1.58) for overweight in young adulthood and 1.78 (95% CI: 1.003-3.16) for obesity in young adulthood, whereas adjusted RR for hemorrhagic stroke was 1.25 (95% CI: .83-1.90) for overweight in young adulthood and 1.80 (95% CI: .97-3.35) for obesity in young adulthood. CONCLUSIONS: Overweight and obesity in young adulthood are associated with an increased risk of stroke, probably, independent of other cardiovascular risk factors. The risk effect gradually increases with increasing body weight.
BACKGROUND: A systematic review assessing the association between overweight and obesity in young adulthood and stroke risk is lacking. Therefore, we conducted a meta-analysis to evaluate the association between overweight and obesity in young adulthood and stroke risk. METHODS: We systematically searched PubMed and Embase databases for related studies of human subjects in the English language. Two investigators independently selected original studies in a 2-step process. Fixed- and random-effects models were used to calculate pooled relative risks (RRs) and 95% confidence intervals (CIs). Subgroup analyses were also performed. RESULTS: Eight studies met the inclusion criteria. The pooled adjusted RR of stroke was 1.36 (95% CI: 1.28-1.44) for overweight in young adulthood and 1.81 (95% CI: 1.45-2.25) for obesity in young adulthood. In subgroup analyses, overweight and obesity in young adulthood increased the risk of stroke in most groups, except for the group of stroke subtype. For ischemic stroke, the adjusted RR was 1.40 (95% CI: 1.24-1.58) for overweight in young adulthood and 1.78 (95% CI: 1.003-3.16) for obesity in young adulthood, whereas adjusted RR for hemorrhagic stroke was 1.25 (95% CI: .83-1.90) for overweight in young adulthood and 1.80 (95% CI: .97-3.35) for obesity in young adulthood. CONCLUSIONS: Overweight and obesity in young adulthood are associated with an increased risk of stroke, probably, independent of other cardiovascular risk factors. The risk effect gradually increases with increasing body weight.
Authors: N Jeanie Santaularia; Majel R Baker; Darin Erickson; Patricia Frazier; Melissa N Laska; Katherine Lust; Susan M Mason Journal: Prev Med Date: 2021-02-23 Impact factor: 4.018
Authors: Sandro Marini; Jordi Merino; Bailey E Montgomery; Rainer Malik; Catherine L Sudlow; Martin Dichgans; Jose C Florez; Jonathan Rosand; Dipender Gill; Christopher D Anderson Journal: Ann Neurol Date: 2020-02-19 Impact factor: 10.422