| Literature DB >> 27618194 |
Marta Ondrésik1,2, Fatima R Azevedo Maia1,2, Alain da Silva Morais1,2,3, Ana C Gertrudes1,2,3, Ana H Dias Bacelar1,2,3, Cristina Correia1,2,3, Cristiana Gonçalves1,2,3, Hajer Radhouani1,2,3, Rui Amandi Sousa1,2,3, Joaquim M Oliveira1,2, Rui L Reis1,2.
Abstract
Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2017;114: 717-739.Entities:
Keywords: articular cartilage; biomaterials; gene therapy; osteoarthritis; regeneration; scaffolds; tissue engineering; viscosupplementation
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Year: 2016 PMID： 27618194 DOI： 10.1002/bit.26182
Source DB: PubMed Journal: Biotechnol Bioeng ISSN： 0006-3592 Impact factor: 4.530