Literature DB >> 27617337

Alpha-1-Antitrypsin Antagonizes Cisplatin-Induced Cytotoxicity in Prostate Cancer (PC3) and Melanoma Cancer (A375) Cell Lines.

Mila Ljujic1, Sanja Mijatovic2, Mirna Z Bulatovic2, Marija Mojic2, Danijela Maksimovic-Ivanic2, Dragica Radojkovic1, Aleksandra Topic3.   

Abstract

Increased circulating alpha-1-antitrypsin (AAT) correlates with cancer stage/aggressiveness, but its role in cancer biology is unclear. We revealed antagonistic effect of AAT to cisplatin-induced cytotoxicity in prostate (PC3) and melanoma (A375) cancer cell lines. Moreover, AAT abrogated cytotoxicity of MEK inhibitor U0126 in PC3 cell line. Weaker antagonistic effect of AAT on cytotoxicity of PI3/Akt and NF-kB inhibitors was also observed. In addition, cisplatin increased AAT gene expression in transfected PC3 cells. However, AAT derived from transfected PC3 cells did not antagonize cisplatin-induced cytotoxicity. In conclusion, these results suggest possible association between high circulating AAT and cisplatin resistance.

Entities:  

Keywords:  Alpha-1-antitrypsin; Cisplatin; Melanoma cancer; Prostate cancer

Mesh：

Substances：

Year:  2016        PMID： 27617337     DOI： 10.1007/s12253-016-0104-3

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  49 in total

1.  Alpha1-antitrypsin deficiency carriers, serum alpha 1-antitrypsin concentration, and non-small cell lung cancer survival.

Authors:  Yan Li; Michael J Krowka; Yingwei Qi; Jerry A Katzmann; Yong Song; Yafei Li; Sumithra J Mandrekar; Ping Yang
Journal:  J Thorac Oncol       Date:  2011-02       Impact factor: 15.609

2.  Alpha-1-antitrypsin stimulates fibroblast proliferation and procollagen production and activates classical MAP kinase signalling pathways.

Authors:  K Dabbagh; G J Laurent; A Shock; P Leoni; J Papakrivopoulou; R C Chambers
Journal:  J Cell Physiol       Date:  2001-01       Impact factor: 6.384

3.  alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis.

Authors:  Irina Petrache; Iwona Fijalkowska; Terry R Medler; Jarrett Skirball; Pedro Cruz; Lijie Zhen; Horia I Petrache; Terence R Flotte; Rubin M Tuder
Journal:  Am J Pathol       Date:  2006-10       Impact factor: 4.307

4.  Identification of α1-antitrypsin as a potential prognostic biomarker for advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors by proteomic analysis.

Authors:  Wei Zhao; Zhen Yang; Xingchen Liu; Qing Tian; Yongzhuang Lv; Yuan Liang; Chunsun Li; Xiaofang Gao; Liangan Chen
Journal:  J Int Med Res       Date:  2013-04-23       Impact factor: 1.671

5.  Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma.

Authors:  Mary Ann Comunale; Lucy Rodemich-Betesh; Julie Hafner; Mengjun Wang; Pamela Norton; Adrian M Di Bisceglie; Timothy Block; Anand Mehta
Journal:  PLoS One       Date:  2010-08-25       Impact factor: 3.240

6.  JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.

Authors:  Yongjie Wei; Sophie Pattingre; Sangita Sinha; Michael Bassik; Beth Levine
Journal:  Mol Cell       Date:  2008-06-20       Impact factor: 17.970

7.  Diverse responses between human pancreatic cancer cell lines to native alpha 1-antitrypsin and its C-terminal fragment.

Authors:  Inga Zelvyte; Bodil Ohlsson; Jan Axelson; Sabina Janciauskiene
Journal:  Anticancer Res       Date:  2003 May-Jun       Impact factor: 2.480

8.  The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.

Authors:  B Woźniak; C Mila-Kierzenkowska; A Woźniak; G Drewa; M Sopońska; T Drewa; E Krzyzyńska-Malinowska; R Makarewicz; T Kowalski; K Szmytkowska
Journal:  Eur J Gynaecol Oncol       Date:  2008       Impact factor: 0.196

Review 9.  Cisplatin and platinum drugs at the molecular level. (Review).

Authors:  Teni Boulikas; Maria Vougiouka
Journal:  Oncol Rep       Date:  2003 Nov-Dec       Impact factor: 3.906

10.  Discovery of tumor markers for gastric cancer by proteomics.

Authors:  Jeng-Yih Wu; Chun-Chia Cheng; Jaw-Yuan Wang; Deng-Chyang Wu; Jan-Sing Hsieh; Shui-Cheng Lee; Wen-Ming Wang
Journal:  PLoS One       Date:  2014-01-03       Impact factor: 3.240
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