Literature DB >> 27617139

The Genetics of Urinary Tract Infections and the Innate Defense of the Kidney and Urinary tract.

Ines Ambite1, Gustav Rydstrom1, Andrew L Schwaderer2, David S Hains3.   

Abstract

The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation. We also comprehensively cover murine knockout models of UTI, genetic variations involved in renal scarring as a result of ascending UTIs, and asymptomatic bacteriuria.

Entities:  

Keywords:  asymptomatic bacteriuria; genetics; innate immunity; urinary tract infections

Year:  2015        PMID： 27617139      PMCID： PMC4918704          DOI： 10.1055/s-0035-1557110

Source DB:  PubMed          Journal:  J Pediatr Genet        ISSN： 2146-460X


  75 in total

1.  Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy?

Authors:  J C Craig; L M Irwig; J F Knight; L P Roy
Journal:  Pediatrics       Date:  2000-06       Impact factor: 7.124

Review 2.  Antibacterial peptides: key components needed in immunity.

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Journal:  Cell       Date:  1991-04-19       Impact factor: 41.582

3.  Uromodulin facilitates neutrophil migration across renal epithelial monolayers.

Authors:  Marianne Schmid; Sinikka Prajczer; Leonhard N Gruber; Cristina Bertocchi; Rosaria Gandini; Walter Pfaller; Paul Jennings; Michael Joannidis
Journal:  Cell Physiol Biochem       Date:  2010-08-24

4.  Carbonic anhydrase 2 deficiency leads to increased pyelonephritis susceptibility.

Authors:  David S Hains; Xi Chen; Vijay Saxena; Evan Barr-Beare; Weisi Flemming; Robert Easterling; Brian Becknell; George J Schwartz; Andrew L Schwaderer
Journal:  Am J Physiol Renal Physiol       Date:  2014-08-20

5.  α-Intercalated cells defend the urinary system from bacterial infection.

Authors:  Neal Paragas; Ritwij Kulkarni; Max Werth; Kai M Schmidt-Ott; Catherine Forster; Rong Deng; Qingyin Zhang; Eugenia Singer; Alexander D Klose; Tian Huai Shen; Kevin P Francis; Sunetra Ray; Soundarapandian Vijayakumar; Samuel Seward; Mary E Bovino; Katherine Xu; Yared Takabe; Fábio E Amaral; Sumit Mohan; Rebecca Wax; Kaitlyn Corbin; Simone Sanna-Cherchi; Kiyoshi Mori; Lynne Johnson; Thomas Nickolas; Vivette D'Agati; Chyuan-Sheng Lin; Andong Qiu; Qais Al-Awqati; Adam J Ratner; Jonathan Barasch
Journal:  J Clin Invest       Date:  2014-06-17       Impact factor: 14.808

6.  Toll-like receptor 4 promoter polymorphisms: common TLR4 variants may protect against severe urinary tract infection.

Authors:  Bryndís Ragnarsdóttir; Klas Jönsson; Alexander Urbano; Jenny Grönberg-Hernandez; Nataliya Lutay; Martti Tammi; Mattias Gustafsson; Ann-Charlotte Lundstedt; Irene Leijonhufvud; Diana Karpman; Björn Wullt; Lennart Truedsson; Ulf Jodal; Björn Andersson; Catharina Svanborg
Journal:  PLoS One       Date:  2010-05-20       Impact factor: 3.240

7.  Evaluation of DMSA scintigraphy and urography in assessing both acute and permanent renal damage in children.

Authors:  E Stokland; M Hellström; B Jacobsson; U Jodal; R Sixt
Journal:  Acta Radiol       Date:  1998-07       Impact factor: 1.990

8.  Reduced toll-like receptor 4 expression in children with asymptomatic bacteriuria.

Authors:  Bryndís Ragnarsdóttir; Martin Samuelsson; Mattias C U Gustafsson; Irene Leijonhufvud; Diana Karpman; Catharina Svanborg
Journal:  J Infect Dis       Date:  2007-06-21       Impact factor: 5.226

9.  Correlation of P blood group, vesicoureteral reflux, and bacterial attachment in patients with recurrent pyelonephritis.

Authors:  H Lomberg; L A Hanson; B Jacobsson; U Jodal; H Leffler; C S Edén
Journal:  N Engl J Med       Date:  1983-05-19       Impact factor: 91.245

10.  Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women.

Authors:  Thomas R Hawn; Delia Scholes; Hongwei Wang; Sue S Li; Ann E Stapleton; Marta Janer; Alan Aderem; Walter E Stamm; Lue Ping Zhao; Thomas M Hooton
Journal:  PLoS One       Date:  2009-12-15       Impact factor: 3.240
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  2 in total

1.  DCHS1 DNA copy number loss associated with pediatric urinary tract infection risk.

Authors:  Aslam H Qureshi; Dong Liang; Jorge Canas; Jenaya Hooks; Samuel W Arrregui; Vijay Saxena; Robert Rooney; Vikki Nolan; Andrew L Schwaderer; David S Hains
Journal:  Innate Immun       Date:  2020-04-15       Impact factor: 2.680

2.  A Putative Role of Apolipoprotein L1 Polymorphism in Renal Parenchymal Scarring Following Febrile Urinary Tract Infection in Nigerian Under-Five Children: Proposal for a Case-Control Association Study.

Authors:  Emmanuel Ademola Anigilaje
Journal:  JMIR Res Protoc       Date:  2018-06-14
  2 in total

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