| Literature DB >> 27617110 |
Walter M Sweeney1, Steve T Lanier1, Chad A Purnell1, Arun K Gosain1.
Abstract
Velopharyngeal insufficiency (VPI) can occur in the setting of an unrepaired or repaired cleft lip and palate. The rate of VPI has been documented as high as 33% in some studies with higher rates of recurrences following surgery associated with genetic syndromes such as 22q11.2 deletions. The primary cause of VPI in these groups is still identified as the anatomic abnormalities of the velum. In this review, the anatomy and physiology of the velum are discussed along with genetic mutations associated with VPI.Entities:
Keywords: cleft palate; genetics; palate anatomy; palate physiology; velopharyngeal insufficiency; velopharynx
Year: 2015 PMID： 27617110 PMCID： PMC4906421 DOI： 10.1055/s-0035-1554978
Source DB: PubMed Journal: J Pediatr Genet ISSN： 2146-460X