| Literature DB >> 27616754 |
Xiao Tan1, Xuesen Cao2,3, Jianzhou Zou2,3, Bo Shen2,3, Xiaoyan Zhang1,2, Zhonghua Liu2,3, Wenlv Lv2,3, Jie Teng2,3, Xiaoqiang Ding1,2,3.
Abstract
Chronic kidney disease (CKD) is an increasingly recognized disease with high global incidence and mortality. Yet, the existing diagnostic tools are not sufficient enough to predict prognosis of CKD and CKD comorbidities. Indoxyl sulfate, a typical uremic toxin, is of great importance in the development of CKD with its nephrotoxicity, cardiovascular toxicity, and bone toxicity. Some reports suggest that indoxyl sulfate directly associate with renal function loss and mortality in CKD patients. This review discusses the diagnostic value of indoxyl sulfate from its biological characteristics, pathophysiological effects, related therapies, and its diagnostic value in clinical studies.Entities:
Keywords: Indoxly sulfate; cardiovascular disease; chronic kidney disease; dialysis; mineral and bone disorder
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Year: 2016 PMID： 27616754 DOI： 10.1111/hdi.12483
Source DB: PubMed Journal: Hemodial Int ISSN： 1492-7535 Impact factor: 1.812