Literature DB >> 27616199

Diapeutic cancer-targeting alkylphosphocholine analogs may advance management of brain malignancies.

Ray R Zhang1,2, Kyle I Swanson1, Lance T Hall2, Jamey P Weichert2,3, John S Kuo1,3.   

Abstract

The following is a special report on alkylphosphocholine analogs as targeted imaging and therapy agents for cancer, and their potential role in diagnosis and treatment in glioblastoma and brain metastases. These novel cancer-targeting agents display impressive tumor avidity with low background in the normal brain, and multimodal diagnostic imaging and therapy capabilities. The use of these agents may significantly improve diagnosis, treatment and post-treatment follow-up in patients with brain malignancies.

Entities:  

Keywords:  cancer imaging; cancer therapy; contrast agents; fluorescence-guided surgery; glioblastoma multiforme; multimodality imaging; personalized medicine; theranostics

Mesh：

Substances：

Year:  2016        PMID： 27616199      PMCID： PMC5514628          DOI： 10.2217/cns-2016-0017

Source DB:  PubMed          Journal:  CNS Oncol        ISSN： 2045-0907


  31 in total

1.  Alkylphosphocholine analogs for broad-spectrum cancer imaging and therapy.

Authors:  Jamey P Weichert; Paul A Clark; Irawati K Kandela; Abram M Vaccaro; William Clarke; Marc A Longino; Anatoly N Pinchuk; Mohammed Farhoud; Kyle I Swanson; John M Floberg; Joseph Grudzinski; Benjamin Titz; Anne M Traynor; Hong-En Chen; Lance T Hall; Christopher J Pazoles; Perry J Pickhardt; John S Kuo
Journal:  Sci Transl Med       Date:  2014-06-11       Impact factor: 17.956

2.  Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.

Authors:  Walter Stummer; Uwe Pichlmeier; Thomas Meinel; Otmar Dieter Wiestler; Friedhelm Zanella; Hans-Jürgen Reulen
Journal:  Lancet Oncol       Date:  2006-05       Impact factor: 41.316

3.  Breast cancer imaging using the near-infrared fluorescent agent, CLR1502.

Authors:  Melissa L Korb; Jason M Warram; Joseph Grudzinski; Jamey Weichert; Justin Jeffery; Eben L Rosenthal
Journal:  Mol Imaging       Date:  2014       Impact factor: 4.488

Review 4.  Imaging of low- and intermediate-grade gliomas.

Authors:  P E Ricci; D H Dungan
Journal:  Semin Radiat Oncol       Date:  2001-04       Impact factor: 5.934

5.  Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas.

Authors:  Matthew J McGirt; Kaisorn L Chaichana; Frank J Attenello; Jon D Weingart; Khoi Than; Peter C Burger; Alessandro Olivi; Henry Brem; Alfredo Quinoñes-Hinojosa
Journal:  Neurosurgery       Date:  2008-10       Impact factor: 4.654

Review 6.  Demographics of brain metastasis.

Authors:  J D Johnson; B Young
Journal:  Neurosurg Clin N Am       Date:  1996-07       Impact factor: 2.509

7.  Brain metastases in children.

Authors:  F Graus; R W Walker; J C Allen
Journal:  J Pediatr       Date:  1983-10       Impact factor: 4.406

8.  Independent association of extent of resection with survival in patients with malignant brain astrocytoma.

Authors:  Matthew J McGirt; Kaisorn L Chaichana; Muraya Gathinji; Frank J Attenello; Khoi Than; Alessandro Olivi; Jon D Weingart; Henry Brem; Alf Redo Quiñones-Hinojosa
Journal:  J Neurosurg       Date:  2009-01       Impact factor: 5.115

9.  Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model.

Authors:  Paul A Clark; Abraham J Al-Ahmad; Tongcheng Qian; Ray R Zhang; Hannah K Wilson; Jamey P Weichert; Sean P Palecek; John S Kuo; Eric V Shusta
Journal:  Mol Pharm       Date:  2016-08-04       Impact factor: 4.939

Review 10.  Anticancer mechanisms and clinical application of alkylphospholipids.

Authors:  Wim J van Blitterswijk; Marcel Verheij
Journal:  Biochim Biophys Acta       Date:  2012-11-05
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  7 in total

Review 1.  Beyond the margins: real-time detection of cancer using targeted fluorophores.

Authors:  Ray R Zhang; Alexandra B Schroeder; Joseph J Grudzinski; Eben L Rosenthal; Jason M Warram; Anatoly N Pinchuk; Kevin W Eliceiri; John S Kuo; Jamey P Weichert
Journal:  Nat Rev Clin Oncol       Date:  2017-01-17       Impact factor: 66.675

2.  PET/CT imaging of the diapeutic alkylphosphocholine analog 124I-CLR1404 in high and low-grade brain tumors.

Authors:  Lance T Hall; Benjamin Titz; H Ian Robins; Bryan P Bednarz; Scott B Perlman; Jamey P Weichert; John S Kuo
Journal:  Am J Nucl Med Mol Imaging       Date:  2017-09-01

3.  [124I]CLR1404 PET/CT in High-Grade Primary and Metastatic Brain Tumors.

Authors:  Lance T Hall; Benjamin Titz; Nishanta Baidya; Anja G van der Kolk; H Ian Robins; Mario Otto; Scott B Perlman; Jamey P Weichert; John S Kuo
Journal:  Mol Imaging Biol       Date:  2020-04       Impact factor: 3.488

4.  In Silico Docking of Alkylphosphocholine Analogs to Human Serum Albumin Predicts Partitioning and Pharmacokinetics.

Authors:  Ray R Zhang; Joseph J Grudzinksi; Tej I Mehta; Ronald R Burnette; Reinier Hernandez; Paul A Clark; Jonathan A Lubin; Anatoly N Pinchuk; Justin Jeffrey; Marc Longino; John S Kuo; Jamey P Weichert
Journal:  Mol Pharm       Date:  2019-07-08       Impact factor: 4.939

5.  Next-Generation Cancer Magnetic Resonance Imaging With Tumor-Targeted Alkylphosphocholine Metal Analogs.

Authors:  Ray R Zhang; Cynthia Choi; Christina L Brunnquell; Reinier Hernandez; Anatoly N Pinchuk; Joseph G Grudzinski; Paul A Clark; Alan B McMillan; Anjon Audhya; Justin Jeffrey; John S Kuo; Jamey P Weichert
Journal:  Invest Radiol       Date:  2022-06-22       Impact factor: 10.065

Review 6.  The analytical and biomedical applications of carbon dots and their future theranostic potential: A review.

Authors:  Sukunya Ross; Ren-Siang Wu; Shih-Chun Wei; Gareth M Ross; Huan-Tsung Chang
Journal:  J Food Drug Anal       Date:  2020-12-15       Impact factor: 6.157

7.  Yeast display biopanning identifies human antibodies targeting glioblastoma stem-like cells.

Authors:  Michael Zorniak; Paul A Clark; Benjamin J Umlauf; Yongku Cho; Eric V Shusta; John S Kuo
Journal:  Sci Rep       Date:  2017-11-20       Impact factor: 4.379
  7 in total

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