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Literature DB >> 27616140

Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome.

Aaron C Anselmo¹, Kevin J McHugh¹, Jamie Webster¹, Robert Langer¹, Ana Jaklenec¹.

Abstract

The gastrointestinal (GI) microbiome is widely investigated for its role in many diseases. However, technologies designed for microbiome delivery are lacking. Here, a layer-by-layer (LbL) approach is reported for probiotic encapsulation to protect probiotics against GI tract insults and improve their adhesion and growth on the intestines. These advantages translate to significantly enhanced survival of LbL-probiotics in vivo.

Entities: Chemical Disease Species

Keywords: biomaterials; gastrointestinal tract; microbiome; oral delivery

Mesh：

Substances：
Bile Acids and Salts

Year: 2016 PMID： 27616140 PMCID： PMC5287492 DOI： 10.1002/adma.201603270

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

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