Jayagopi Surendar1, Karunakaran Indulekha1, Viswanathan Mohan2, Rajendra Pradeepa1. 1. Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention & Control, Gopalapuram, Chennai, India. 2. Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention & Control, Gopalapuram, Chennai, India. Electronic address: drmohans@diabetes.ind.in.
Abstract
BACKGROUND: Metabolic syndrome (MS) is the state of chronic low grade inflammation. This study looks at the relationship of neutrophil-lymphocyte ratio (NLR) in subjects with and without MS in Asian Indians. METHODS: Study subjects (n=754) were recruited from the Chennai Urban Rural Epidemiology Study. MS was defined using the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III criteria modified for waist according to World Health Organization Asia Pacific guidelines. A complete hemogram was done in all subjects using a five-part hematology analyzer (model SF-3000; Sysmex, Kobe, Japan). The NLR was calculated as the ratio between counts for neutrophils and total lymphocytes in subjects with (n=422) and without (n332) MS and correlated with number of metabolic abnormalities in those with MS. RESULTS: Subjects with five metabolic abnormalities had the highest NLR, and with decreasing number of metabolic abnormalities, the NLR decreased linearly (p for trend <0.001). Logistic regression analysis revealed that even after adjusting for age, gender and body mass index, MS was strongly associated with NLR (p<0.001). CONCLUSION: Among Asian Indians, NLR is correlated with MS and also with the number of metabolic abnormalities.
BACKGROUND:Metabolic syndrome (MS) is the state of chronic low grade inflammation. This study looks at the relationship of neutrophil-lymphocyte ratio (NLR) in subjects with and without MS in Asian Indians. METHODS: Study subjects (n=754) were recruited from the Chennai Urban Rural Epidemiology Study. MS was defined using the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III criteria modified for waist according to World Health Organization Asia Pacific guidelines. A complete hemogram was done in all subjects using a five-part hematology analyzer (model SF-3000; Sysmex, Kobe, Japan). The NLR was calculated as the ratio between counts for neutrophils and total lymphocytes in subjects with (n=422) and without (n332) MS and correlated with number of metabolic abnormalities in those with MS. RESULTS: Subjects with five metabolic abnormalities had the highest NLR, and with decreasing number of metabolic abnormalities, the NLR decreased linearly (p for trend <0.001). Logistic regression analysis revealed that even after adjusting for age, gender and body mass index, MS was strongly associated with NLR (p<0.001). CONCLUSION: Among Asian Indians, NLR is correlated with MS and also with the number of metabolic abnormalities.
Authors: Víctor Micó; Rodrigo San-Cristobal; Roberto Martín; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Montserrat Fitó; Ángel M Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramon Estruch; Francisco J Tinahones; José Lapetra; J Luís Serra-Majem; Aurora Bueno-Cavanillas; Josep A Tur; Vicente Martín Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Ana García-Arellano; Salvador Pertusa-Martinez; Alice Chaplin; Antonio Garcia-Rios; Carlos Muñoz Bravo; Helmut Schröder; Nancy Babio; Jose V Sorli; Jose I Gonzalez; Diego Martinez-Urbistondo; Estefania Toledo; Vanessa Bullón; Miguel Ruiz-Canela; María Puy- Portillo; Manuel Macías-González; Nuria Perez-Diaz-Del-Campo; Jesús García-Gavilán; Lidia Daimiel; J Alfredo Martínez Journal: Front Endocrinol (Lausanne) Date: 2022-09-06 Impact factor: 6.055