Kharah MacKenzie Ross1, Gregory Miller2,3, Jennifer Culhane4,5, William Grobman6,7, Hyagriv N Simhan8,9, Pathik D Wadhwa10, Douglas Williamson11, Thomas McDade3,12, Claudia Buss10,13, Sonja Entringer10,13, Emma Adam3,14, Sameen Qadir15, Lauren Keenan-Devlin16, Adam K K Leigh2, Ann Borders7,17,18. 1. Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA. kross@psych.ucla.edu. 2. Department of Psychology, Northwestern University, Evanston, IL, USA. 3. Institute for Policy Research, Northwestern University, Evanston, IL, USA. 4. Division of Adolescent Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. 5. Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. 6. Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 7. Center for Healthcare Studies, Institute for Public Health and Medicine, Chicago, IL, USA. 8. Division of Maternal-Fetal Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 9. Division of Obstetrical Services, Magee Women's Hospital, Pittsburgh, PA, USA. 10. UCI Development, Health and Disease Research Program, University of California Irvine, Irvine, CA, USA. 11. Department of Psychiatry and Behavioral Services, Duke University, Durham, NC, USA. 12. Department of Anthropology, Northwestern University, Evanston, IL, USA. 13. Charite Universitätsmedizin Berlin, Berlin, Germany. 14. School of Education and Social Policy, Northwestern University, Evanston, IL, USA. 15. Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA. 16. Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, NorthShore University Health System, Evanston, IL, USA. 17. Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. 18. Department of Obsetrics and Gynecology, Division of Maternal Fetal Medicine, NorthShore University Health System, University of Chicago Pritzker School of Medicine, Evanston, IL, USA.
Abstract
PROBLEM: Maternal inflammation undergoes adaptations during pregnancy, and excessive inflammation has been associated with adverse outcomes. One mechanism may be maternal inflammation transmission to the fetal compartment. Links between maternal pregnancy inflammation and fetal inflammation are poorly characterized. METHOD: Principal components analysis was used to extract underlying inflammation components across cytokines (IFN-γ, IL-10, IL-13, IL-6, IL-8, TNF-α) in two pregnancy cohorts (SPAH N=87, MOMS N=539) assessed during the second and third trimesters. Links between maternal inflammation over pregnancy and fetal (cord blood) inflammation were assessed. RESULTS: Substantial cytokine rank-order stability was observed in both cohorts, β's range .47-.96, P's <.001. Two consistent inflammatory components were extracted: a pro-inflammatory (IL-10, IL-6, IL-8, TNF-α, IFN-γ) component and anti-inflammatory (IL-13) component. Higher maternal pro-inflammatory and lower anti-inflammatory indices during pregnancy were associated with higher cord blood inflammation, P's>.04. CONCLUSION: Maternal inflammation indices over pregnancy were associated with inflammation in cord blood at birth. Results have implications for understanding pregnancy inflammatory processes and how maternal inflammation may be transmitted to fetal circulation.
PROBLEM: Maternal inflammation undergoes adaptations during pregnancy, and excessive inflammation has been associated with adverse outcomes. One mechanism may be maternal inflammation transmission to the fetal compartment. Links between maternal pregnancy inflammation and fetal inflammation are poorly characterized. METHOD: Principal components analysis was used to extract underlying inflammation components across cytokines (IFN-γ, IL-10, IL-13, IL-6, IL-8, TNF-α) in two pregnancy cohorts (SPAH N=87, MOMS N=539) assessed during the second and third trimesters. Links between maternal inflammation over pregnancy and fetal (cord blood) inflammation were assessed. RESULTS: Substantial cytokine rank-order stability was observed in both cohorts, β's range .47-.96, P's <.001. Two consistent inflammatory components were extracted: a pro-inflammatory (IL-10, IL-6, IL-8, TNF-α, IFN-γ) component and anti-inflammatory (IL-13) component. Higher maternal pro-inflammatory and lower anti-inflammatory indices during pregnancy were associated with higher cord blood inflammation, P's>.04. CONCLUSION:Maternal inflammation indices over pregnancy were associated with inflammation in cord blood at birth. Results have implications for understanding pregnancy inflammatory processes and how maternal inflammation may be transmitted to fetal circulation.
Authors: Claudia Lazarides; Elissa S Epel; Jue Lin; Elizabeth H Blackburn; Manuel C Voelkle; Claudia Buss; Hyagriv N Simhan; Pathik D Wadhwa; Sonja Entringer Journal: Brain Behav Immun Date: 2019-04-08 Impact factor: 7.217
Authors: Gregory E Miller; Jennifer Culhane; William Grobman; Hyagriv Simhan; Douglas E Williamson; Emma K Adam; Claudia Buss; Sonja Entringer; Kwang-Youn Kim; J Felipe Garcia-Espana; Lauren Keenan-Devlin; Thomas W McDade; Pathik D Wadhwa; Ann Borders Journal: Brain Behav Immun Date: 2017-04-25 Impact factor: 7.217
Authors: Emily S Miller; William A Grobman; Jennifer Culhane; Emma Adam; Claudia Buss; Sonja Entringer; Gregory Miller; Pathik D Wadhwa; Lauren Keenan-Devlin; Ann Borders Journal: Arch Womens Ment Health Date: 2018-06-04 Impact factor: 3.633
Authors: Chloe Friedman; Dana Dabelea; Deborah S K Thomas; Jennifer L Peel; John L Adgate; Sheryl Magzamen; Sheena E Martenies; William B Allshouse; Anne P Starling Journal: Environ Res Date: 2021-04-20 Impact factor: 8.431
Authors: Heather E Volk; Bo Park; Calliope Hollingue; Karen L Jones; Paul Ashwood; Gayle C Windham; Fred Lurman; Stacey E Alexeeff; Martin Kharrazi; Michelle Pearl; Judy Van de Water; Lisa A Croen Journal: J Neurodev Disord Date: 2020-12-16 Impact factor: 4.025