Somayeh Salehi1, Amir Hossein Jafarian1, Mehdi Montazer2, Meysam Moghbeli3, Mohammad Mahdi Forghanifard4. 1. Cancer Molecular Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Dr Moaven Hospital, Kermanshah University of Medical Sciences, Sahneh, Kermanshah, Iran. 3. Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran. 4. Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran. forghanifard@gmail.com.
Abstract
PURPOSE: Evading apoptosis is one of the major hallmarks of cancer cells. Inhibitors of apoptosis (IAPs) proteins are considered as a most important gene families involved in apoptosis. BRUCE protein, a member of IAPs, is able to quench apoptosis as well as playing role in cell division. Our aim in this study was to analyze BRUCE protein expression in gastric carcinoma (GC) and its correlation with the clinicopathological features. METHODS: Using immunohistochemistry, 52 GC specimens were studied for BRUCE protein expression. A validated scoring method was applied. RESULTS: BRUCE protein expression was detected in majority of tumor tissues (98.07 %). A significant correlation between gender and BRUCE expression (p = 0.024) was detected. Indeed, females showed higher level of BRUCE expression than male patients. CONCLUSION: Since specific expression of BRUCE protein was revealed in majority of GC tissues, BRUCE protein may be a useful therapeutic target for cancer therapy. Furthermore, based on the native role of BRUCE protein in inhibition of apoptosis, using this protein in targeted therapy of tumor cells may help to inhibit tumor cells growth and survival leading to rapid elimination of tumor mass.
PURPOSE: Evading apoptosis is one of the major hallmarks of cancer cells. Inhibitors of apoptosis (IAPs) proteins are considered as a most important gene families involved in apoptosis. BRUCE protein, a member of IAPs, is able to quench apoptosis as well as playing role in cell division. Our aim in this study was to analyze BRUCE protein expression in gastric carcinoma (GC) and its correlation with the clinicopathological features. METHODS: Using immunohistochemistry, 52 GC specimens were studied for BRUCE protein expression. A validated scoring method was applied. RESULTS:BRUCE protein expression was detected in majority of tumor tissues (98.07 %). A significant correlation between gender and BRUCE expression (p = 0.024) was detected. Indeed, females showed higher level of BRUCE expression than male patients. CONCLUSION: Since specific expression of BRUCE protein was revealed in majority of GC tissues, BRUCE protein may be a useful therapeutic target for cancer therapy. Furthermore, based on the native role of BRUCE protein in inhibition of apoptosis, using this protein in targeted therapy of tumor cells may help to inhibit tumor cells growth and survival leading to rapid elimination of tumor mass.
Authors: Jinyu Ren; Mingan Shi; Renshui Liu; Qi-Heng Yang; Teri Johnson; William C Skarnes; Chunying Du Journal: Proc Natl Acad Sci U S A Date: 2005-01-07 Impact factor: 11.205
Authors: Fieke Lamers; Linda Schild; Jan Koster; Frank Speleman; Ingrid Øra; Ellen M Westerhout; Peter van Sluis; Rogier Versteeg; Huib N Caron; Jan J Molenaar Journal: BMC Cancer Date: 2012-07-12 Impact factor: 4.430
Authors: A Lopergolo; M Pennati; P Gandellini; N I Orlotti; P Poma; M G Daidone; M Folini; N Zaffaroni Journal: Br J Cancer Date: 2009-02-17 Impact factor: 7.640