Maria Ida Maiorino1, Giuseppe Bellastella2, Mariangela Caputo3, Filomena Castaldo4, Maria Rosaria Improta5, Dario Giugliano6, Katherine Esposito7. 1. Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy. Electronic address: mariaida.maiorino@unina2.it. 2. Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy. Electronic address: giuseppe.bellastella@unina2.it. 3. Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy. Electronic address: marycapu_2008@libero.it. 4. Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy. Electronic address: castaldomena@libero.it. 5. Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy. Electronic address: improtasaria@libero.it. 6. Endocrinology and Metabolic Diseases Unit, Department of Medical, Surgical, Neurological, Metabolic Sciences and Aging, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy. Electronic address: dario.giugliano@unina2.it. 7. Diabetes Unit, Department of Clinical and Experimental Medicine, Second University of Naples, Piazza L. Miraglia n° 2, 80138 Naples, Italy. Electronic address: katherine.esposito@unina2.it.
Abstract
AIMS: To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly diagnosed type 2 diabetes. METHODS: In a randomized clinical trial, with a total follow-up of 8.1years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n=108) or a low-fat diet (n=107). The primary outcome measures were changes of erectile function (IIEF) in diabetic men and of female sexual function (FSFI) in diabetic women. RESULTS: There was no difference in baseline sexual function in men (n=54 vs 52) or women (n=54 vs 55) randomized toMediterranean diet or low-fat diet, respectively (P=0.287, P=0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P=0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted erectile dysfunction in men but not female sexual dysfunction in women. CONCLUSIONS: Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes.
RCT Entities:
AIMS: To assess the long-term effect of Mediterranean diet, as compared with low-fat diet, on sexual function in patients with newly diagnosed type 2 diabetes. METHODS: In a randomized clinical trial, with a total follow-up of 8.1years, 215 men and women with newly diagnosed type 2 diabetes were assigned to Mediterranean diet (n=108) or a low-fat diet (n=107). The primary outcome measures were changes of erectile function (IIEF) in diabeticmen and of female sexual function (FSFI) in diabeticwomen. RESULTS: There was no difference in baseline sexual function in men (n=54 vs 52) or women (n=54 vs 55) randomized to Mediterranean diet or low-fat diet, respectively (P=0.287, P=0.815). Over the entire follow-up, the changes of the primary outcomes were significantly lower in the Mediterranean diet group compared with the low-fat group: IIEF and FSFI showed a significantly lesser decrease (1.22 and 1.18, respectively, P=0.024 and 0.019) with the Mediterranean diet. Baseline C-reactive protein levels predicted erectile dysfunction in men but not female sexual dysfunction in women. CONCLUSIONS: Among persons with newly diagnosed type 2 diabetes, a Mediterranean diet reduced the deterioration of sexual function over time in both sexes.
Authors: Giuseppe Defeudis; Alfonso Maria Di Tommaso; Claudia Di Rosa; Danilo Cimadomo; Yeganeh Manon Khazrai; Antongiulio Faggiano; Raffaele Ivan Cincione; Nicola Napoli; Rossella Mazzilli Journal: J Clin Med Date: 2022-06-13 Impact factor: 4.964
Authors: Scott R Bauer; Benjamin N Breyer; Meir J Stampfer; Eric B Rimm; Edward L Giovannucci; Stacey A Kenfield Journal: JAMA Netw Open Date: 2020-11-02