Nathalie Zamagni Bessa1, Daniela de Oliveira Francisco1, Marina de Paula Andres2, Bárbara Yasmim Gueuvoghlanian-Silva3, Sergio Podgaec2,3, Cintia Fridman4. 1. Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, nº 115, Cerqueira Cesar, CEP: 05405-000, São Paulo, SP, Brazil. 2. Department of Obstetrics and Gynecology, Clinics Hospital, Medical School, University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, 10th floor, Cerqueira Cesar, CEP: 05403-010, São Paulo, SP, Brazil. 3. Jewish Teaching and Research Institute, Albert Einstein Hospital, Avenida Albert Einstein 627, Morumbi, CEP: 05652-900, Sao Paulo, SP, Brazil. 4. Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of São Paulo, Rua Teodoro Sampaio, nº 115, Cerqueira Cesar, CEP: 05405-000, São Paulo, SP, Brazil. cfridman@usp.br.
Abstract
PURPOSE: This study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women. METHODS: We genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms. RESULTS: No significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p = 0.61 and p = 0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p = 0.63 and p = 0.24, respectively). All individuals were wild homozygotes for G241R polymorphism. CONCLUSION: This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.
PURPOSE: This study investigated the possibility of K469E (rs5498) and G241R (rs1799969) polymorphisms, in ICAM-1 gene, and G634C (rs1800796), in IL-6 gene, being associated with the occurrence of endometriosis in a sample of Brazilian women. METHODS: We genotyped 200 women (100 in control group and 100 in endometriosis group) by PCR-RFLP technique for G634C, K469E, and G241R polymorphisms. RESULTS: No significant difference was observed in genotypic frequency between control and endometriosis groups for G634C and K469E polymorphisms (p = 0.61 and p = 0.22, respectively). In addition, no significant difference between stages I-II and III-IV of the disease was found for both SNPs (p = 0.63 and p = 0.24, respectively). All individuals were wild homozygotes for G241R polymorphism. CONCLUSION: This study suggests that polymorphisms K469E, G241R, and G634C are not associated with increased susceptibility to endometriosis in Brazilian women.
Authors: P Viganò; M Infantino; D Lattuada; R Lauletta; E Ponti; E Somigliana; M Vignali; A M DiBlasio Journal: Mol Hum Reprod Date: 2003-01 Impact factor: 4.025
Authors: Andrei M Malutan; Tudor Drugan; Nicolae Costin; Razvan Ciortea; Carmen Bucuri; Maria P Rada; Dan Mihu Journal: Cent Eur J Immunol Date: 2015-04-22 Impact factor: 2.085