| Literature DB >> 27614000 |
Stephan Gasser1, Wendy Y L Zhang2, Nikki Yi Jie Tan2, Shubhita Tripathi2, Manuel A Suter2, Zhi Huan Chew3, Muznah Khatoo2, Joanne Ngeow4, Florence S G Cheung5.
Abstract
The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. Here, we review recent evidence that the cellular response to DNA damage and microbial DNA are tightly intertwined. We also discuss insights into the parameters that enable DNA sensors to distinguish damaged and microbial DNA from DNA present in healthy cells.Entities:
Keywords: Cancer; Cytosolic DNA; DNA repair; DNA sensor; Innate immunity
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Year: 2016 PMID： 27614000 DOI： 10.1016/j.mad.2016.09.001
Source DB: PubMed Journal: Mech Ageing Dev ISSN： 0047-6374 Impact factor: 5.432