Minas Baltatzis1, J M Mason2, Vishnu Chandrabalan1, Panagiotis Stathakis1, Ben McIntyre3, Santhalingam Jegatheeswaran1, Saurabh Jamdar1, Derek A O'Reilly4, Ajith K Siriwardena5. 1. Regional Hepato-Pancreato-Biliary Unit, Manchester Royal Infirmary, Manchester, UK. 2. Warwick Medical School, University of Warwick, Coventry, England, UK. 3. Pharmacy Dept, Manchester Royal Infirmary, Manchester, UK. 4. Regional Hepato-Pancreato-Biliary Unit, Manchester Royal Infirmary, Manchester, UK; University of Manchester, Faculty of Medical and Human Sciences, Manchester, England, UK. 5. Regional Hepato-Pancreato-Biliary Unit, Manchester Royal Infirmary, Manchester, UK; University of Manchester, Faculty of Medical and Human Sciences, Manchester, England, UK. Electronic address: ajith.siriwardena@cmft.nhs.uk.
Abstract
INTRODUCTION: Intravenous antibiotic prophylaxis is not recommended in acute pancreatitis. According to current international guidelines antibiotics together with further intervention should be considered in the setting of infected necrosis. Appropriate antibiotic therapy particularly avoiding over-prescription is important. This study examines antibiotic use in acute pancreatitis in a tertiary centre using the current IAP/APA guidelines for reference. METHODS: Data were collected on a consecutive series of patients admitted with acute pancreatitis over a 12 month period. Data were dichotomized by patients admitted directly to the centre and tertiary transfers. Information was collected on clinical course with specific reference to antibiotic use, episode severity, intervention and outcome. RESULTS: 111 consecutive episodes of acute pancreatitis constitute the reported population. 31 (28%) were tertiary transfers. Overall 65 (58.5%) patients received antibiotics. Significantly more tertiary transfer patients received antibiotics. Mean person-days of antibiotic use was 23.9 (sd 29.7) days in the overall study group but there was significantly more use in the tertiary transfer group as compared to patients having their index admission to the centre (40.9 sd 37.1 vs 10.2 sd 8.9; P < 0.005). Thirty four (44%) of patients with clinically mild acute pancreatitis received antibiotics. CONCLUSIONS: There is substantial use of antibiotics in acute pancreatitis, in particular in patients with severe disease. Over-use is seen in mild acute pancreatitis. Better consideration must be given to identification of prophylaxis or therapy as indication. In relation to repeated courses of antibiotics in severe disease there must be clear indications for use.
INTRODUCTION: Intravenous antibiotic prophylaxis is not recommended in acute pancreatitis. According to current international guidelines antibiotics together with further intervention should be considered in the setting of infected necrosis. Appropriate antibiotic therapy particularly avoiding over-prescription is important. This study examines antibiotic use in acute pancreatitis in a tertiary centre using the current IAP/APA guidelines for reference. METHODS: Data were collected on a consecutive series of patients admitted with acute pancreatitis over a 12 month period. Data were dichotomized by patients admitted directly to the centre and tertiary transfers. Information was collected on clinical course with specific reference to antibiotic use, episode severity, intervention and outcome. RESULTS: 111 consecutive episodes of acute pancreatitis constitute the reported population. 31 (28%) were tertiary transfers. Overall 65 (58.5%) patients received antibiotics. Significantly more tertiary transfer patients received antibiotics. Mean person-days of antibiotic use was 23.9 (sd 29.7) days in the overall study group but there was significantly more use in the tertiary transfer group as compared to patients having their index admission to the centre (40.9 sd 37.1 vs 10.2 sd 8.9; P < 0.005). Thirty four (44%) of patients with clinically mild acute pancreatitis received antibiotics. CONCLUSIONS: There is substantial use of antibiotics in acute pancreatitis, in particular in patients with severe disease. Over-use is seen in mild acute pancreatitis. Better consideration must be given to identification of prophylaxis or therapy as indication. In relation to repeated courses of antibiotics in severe disease there must be clear indications for use.
Authors: Fernanda S Soares; Flávia C Amaral; Natália L C Silva; Matheus R Valente; Lorena K R Santos; Lívia H Yamashiro; Mara C Scheffer; Fernanda V E S Castanheira; Raphael G Ferreira; Laura Gehrke; José C Alves-Filho; Luciano P Silva; André Báfica; Fernando Spiller Journal: Front Immunol Date: 2017-12-22 Impact factor: 7.561