John D Markman1, Troels Staehelin Jensen2, David Semel3, Chunming Li4, Bruce Parsons3, Regina Behar3, Alesia B Sadosky5. 1. Department of Neurosurgery, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA. 2. Danish Pain Research Centre, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark. 3. Medical, Pfizer Inc., New York, USA. 4. Clinical Statistics, Pfizer Inc., New York, USA. 5. Outcomes and Evidence, Pfizer Inc., New York, USA.
Abstract
OBJECTIVES: This analysis compared the therapeutic response of pregabalin in patients with neuropathic pain (NeP) who had been previously treated withgabapentin to the therapeutic response in patients who had not received gabapentin previously. METHODS: Data were pooled from 18 randomized, double-blind, placebo-controlled trials of pregabalin in patients with NeP. Pregabalin-mediated changes in pain and pain-related sleep interference scores, patient global impression of change scores at endpoint, and the occurrence of adverse events were compared between patients who had received gabapentin previously (+GBN) and patients who had not received gabapentin previously (-GBN). RESULTS: There were no significant differences between the -GBN and +GBN cohorts with regard to the extent of pain relief and relief of pain-related sleep interference for any dose of pregabalin (150, 300, 600, or 150 to 600 mg/day) at any time point (6, 8, or 12 weeks). Additionally, there was no significant difference in the distribution of patient global impression of change scores at study endpoint, or the occurrence of adverse events, between the -GBN and +GBN cohorts. DISCUSSION: The findings presented here support the idea that pregabalin may be used successfully to treat patients with NeP who may be refractory, respond inadequately, or are intolerant to gabapentin. These findings highlight the importance of tailoring treatment of NeP based on individual patient response to different treatments, including the trial of multiple agents within the same mechanistic class.
RCT Entities:
OBJECTIVES: This analysis compared the therapeutic response of pregabalin in patients with neuropathic pain (NeP) who had been previously treated with gabapentin to the therapeutic response in patients who had not received gabapentin previously. METHODS: Data were pooled from 18 randomized, double-blind, placebo-controlled trials of pregabalin in patients with NeP. Pregabalin-mediated changes in pain and pain-related sleep interference scores, patient global impression of change scores at endpoint, and the occurrence of adverse events were compared between patients who had received gabapentin previously (+GBN) and patients who had not received gabapentin previously (-GBN). RESULTS: There were no significant differences between the -GBN and +GBN cohorts with regard to the extent of pain relief and relief of pain-related sleep interference for any dose of pregabalin (150, 300, 600, or 150 to 600 mg/day) at any time point (6, 8, or 12 weeks). Additionally, there was no significant difference in the distribution of patient global impression of change scores at study endpoint, or the occurrence of adverse events, between the -GBN and +GBN cohorts. DISCUSSION: The findings presented here support the idea that pregabalin may be used successfully to treat patients with NeP who may be refractory, respond inadequately, or are intolerant to gabapentin. These findings highlight the importance of tailoring treatment of NeP based on individual patient response to different treatments, including the trial of multiple agents within the same mechanistic class.
Authors: Joe Alexander; Roger A Edwards; Marina Brodsky; Luigi Manca; Roberto Grugni; Alberto Savoldelli; Gianluca Bonfanti; Birol Emir; Ed Whalen; Steve Watt; Bruce Parsons Journal: PLoS One Date: 2018-12-06 Impact factor: 3.240
Authors: Arturo Cuomo; Anna Crispo; Andrea Truini; Silvia Natoli; Orazio Zanetti; Paolo Barone; Marco Cascella Journal: J Pain Res Date: 2019-07-22 Impact factor: 3.133
Authors: Joe Alexander; Roger A Edwards; Alberto Savoldelli; Luigi Manca; Roberto Grugni; Birol Emir; Ed Whalen; Stephen Watt; Marina Brodsky; Bruce Parsons Journal: BMC Med Res Methodol Date: 2017-07-20 Impact factor: 4.615