Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Effects of FOXJ2 on TGF-β1-induced epithelial-mesenchymal transition through Notch signaling pathway in non-small lung cancer.

Literature DB >> 27611107

Effects of FOXJ2 on TGF-β1-induced epithelial-mesenchymal transition through Notch signaling pathway in non-small lung cancer.

Qichang Yang¹, Xingjian Cao², Guohua Tao², Feng Zhou², Ping Zhao², Yi Shen¹, Xiang Chen².

Abstract

As one member of Forkhead box transcription factors, Forkhead box J2 (FOXJ2) has been found to be involved in epithelial-mesenchymal transition (EMT) process. However, the role and mechanism of FOXJ2 in non-small cell lung cancer (NSCLC) and EMT regulation have not been fully revealed. In this paper, it was revealed that the expression of FOXJ2 was lower in NSCLC samples compared with matched peritumoral lung tissue. We demonstrated that FOXJ2 expression was down-regulated by transforming growth factor-β1 (TGF-β1) treated, and overexpression of FOXJ2 inhibited TGF-β1-induced EMT. Mechanistically, knocking out the expression of FOXJ2 promoted EMT by increasing the expression of Notch1 and NICD. This study implicates the potential value of FOXJ2 as a molecular marker for NSCLC.

Entities: Disease Gene

Keywords: EMT; FOXJ2; NSCLC; Notch signaling pathway; TGF-β1

Mesh：

Substances：

Year: 2016 PMID： 27611107 DOI： 10.1002/cbin.10680

Source DB: PubMed Journal: Cell Biol Int ISSN： 1065-6995 Impact factor: 3.612

Keyword Cloud
Cited

9 in total

Review 1. The airway epithelium during infancy and childhood: A complex multicellular immune barrier. Basic review for clinicians.

Authors: Xilei Xu-Chen; Jered Weinstock; Deepa Rastogi; Anastassios Koumbourlis; Gustavo Nino
Journal: Paediatr Respir Rev Date: 2021-04-22 Impact factor: 2.726

2. Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke.

Authors: Takaki Hiwasa; Hao Wang; Ken-Ichiro Goto; Seiichiro Mine; Toshio Machida; Eiichi Kobayashi; Yoichi Yoshida; Akihiko Adachi; Tomoo Matsutani; Mizuki Sata; Kazumasa Yamagishi; Hiroyasu Iso; Norie Sawada; Shoichiro Tsugane; Mitoshi Kunimatsu; Ikuo Kamitsukasa; Masahiro Mori; Kazuo Sugimoto; Akiyuki Uzawa; Mayumi Muto; Satoshi Kuwabara; Yoshio Kobayashi; Mikiko Ohno; Eiichiro Nishi; Akiko Hattori; Masashi Yamamoto; Yoshiro Maezawa; Kazuki Kobayashi; Ryoichi Ishibashi; Minoru Takemoto; Koutaro Yokote; Hirotaka Takizawa; Takashi Kishimoto; Kazuyuki Matsushita; Sohei Kobayashi; Fumio Nomura; Takahiro Arasawa; Akiko Kagaya; Tetsuro Maruyama; Hisahiro Matsubara; Minako Tomiita; Shinsaku Hamanaka; Yushi Imai; Tomoo Nakagawa; Naoya Kato; Jiro Terada; Takuma Matsumura; Yusuke Katsumata; Akira Naito; Nobuhiro Tanabe; Seiichiro Sakao; Koichiro Tatsumi; Masaaki Ito; Fumiaki Shiratori; Makoto Sumazaki; Satoshi Yajima; Hideaki Shimada; Mikako Shirouzu; Shigeyuki Yokoyama; Takashi Kudo; Hirofumi Doi; Katsuro Iwase; Hiromi Ashino; Shu-Yang Li; Masaaki Kubota; Go Tomiyoshi; Natsuko Shinmen; Rika Nakamura; Hideyuki Kuroda; Yasuo Iwadate
Journal: BMC Med Date: 2021-06-09 Impact factor: 8.775

3. miR-20a/Foxj2 Axis Mediates Growth and Metastasis of Colorectal Cancer Cells as Identified by Integrated Analysis.

Authors: Yong Qiang; Liang Feng; Gang Wang; Jian Liu; Jing Zhang; Lanlan Xiang; Chunjie Su; Songbai Zhang; Xiongwei Xie; Erlin Chen
Journal: Med Sci Monit Date: 2020-05-14

4. Low FOXJ2 expression is associated with unfavorable postoperative prognosis of patients with epithelial ovarian cancer.

Authors: Yong Li; Xinghua Zhu; Chunhua Liu; Qing Han; Xiaojing Chen; Yushan Liu; Yi Yin; Aiqin He; Fei Xia
Journal: Medicine (Baltimore) Date: 2021-03-12 Impact factor: 1.817

9. Effect of miR‑449a‑mediated Notch signaling pathway on the proliferation, apoptosis and invasion of papillary thyroid carcinoma cells.

Authors: Yujie Hou; Feiling Feng; Ronghua Yang
Journal: Oncol Rep Date: 2019-12-23 Impact factor: 3.906

9 in total

Effects of FOXJ2 on TGF-β1-induced epithelial-mesenchymal transition through Notch signaling pathway in non-small lung cancer.

Review 1. The airway epithelium during infancy and childhood: A complex multicellular immune barrier. Basic review for clinicians.

2. Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke.

3. miR-20a/Foxj2 Axis Mediates Growth and Metastasis of Colorectal Cancer Cells as Identified by Integrated Analysis.

4. Low FOXJ2 expression is associated with unfavorable postoperative prognosis of patients with epithelial ovarian cancer.

5. Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation.

6. Foxj2 overexpression is associated with poor prognosis, progression, and metastasis in nasopharyngeal carcinoma.

7. Sorting nexin-1 is a candidate tumor suppressor and potential prognostic marker in gastric cancer.

8. Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking.

9. Effect of miR‑449a‑mediated Notch signaling pathway on the proliferation, apoptosis and invasion of papillary thyroid carcinoma cells.