| Literature DB >> 27610711 |
Edwin Kroon1, Katarzyna Kurpiewska2, Justyna Kalinowska-Tłuścik2, Alexander Dömling1.
Abstract
β-Cyanoethyl isocyanide is introduced as a cleavable isocyanide in the Ugi tetrazole reaction. Eleven examples are described that exhibit a broad scope and are obtained in good overall yields. The obtained 1H-tetrazole scaffold is an important bioisostere for carboxylic acids, and the method described here is a valuable alternative route to known procedures.Entities:
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Year: 2016 PMID： 27610711 DOI： 10.1021/acs.orglett.6b01826
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005