Literature DB >> 2760966

A preliminary study on expression and significance of pre-S1 protein in liver tissue of patients with HBV infection.

K Q Hu, L J Hao, Y Y Zhang, H Schaller.   

Abstract

Rabbit antiserum to Pre-S1 protein was used to establish peroxidase-antiperoxidase (PAP) and avidin-biotin-peroxidase complex (ABC) immunohistochemical techniques for detection of Pre-S1 protein in paraffin-embedded liver tissue. Pre-S1 protein could be expressed in hepatocyte cytoplasm and on membrane in some cases with chronic viral hepatitis, cirrhosis and hepatocellular carcinoma (HCC), and its expression was intimately associated with HBsAg, HBcAg in liver and HBV DNA in serum, indicating that pre-S1 protein may represent the essential component of hepatitis B virus (HBV) and also serve as one of the markers of HBV infection. The incidence of Pre-S1 protein was slightly lower in nontumorous liver of HCC than in other cases and Pre-S1 protein could not be detected in tumorous tissue of HCC suggesting that expression of pre-S1 protein may be suppressed in HCC cases.

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Year:  1989        PMID： 2760966     DOI： 10.1007/BF02933736

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  12 in total

1.  Immunohistochemical studies on hepatitis B markers in the liver tissue of patients with hepatocellular carcinoma.

Authors:  K Q Hu; P H Song; L J Hao
Journal:  J Tongji Med Univ       Date:  1987

Review 2.  Hepatitis B virus proteins eliciting protective immunity.

Authors:  A R Neurath; B A Jameson; T Huima
Journal:  Microbiol Sci       Date:  1987-02

3.  The unlabeled antibody enzyme method of immunohistochemistry: preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antihorseradish peroxidase) and its use in identification of spirochetes.

Authors:  L A Sternberger; P H Hardy; J J Cuculis; H G Meyer
Journal:  J Histochem Cytochem       Date:  1970-05       Impact factor: 2.479

4.  Demonstration of pre-S polypeptides of hepatitis B virus in infected livers.

Authors:  S N Thung; M A Gerber; E J Kasambalides; B K Gilja; W Keh; W H Gerlich
Journal:  Hepatology       Date:  1986 Nov-Dec       Impact factor: 17.425

5.  A polypeptide containing 55 amino acid residues coded by the pre-S region of hepatitis B virus deoxyribonucleic acid bears the receptor for polymerized human as well as chimpanzee albumins.

Authors:  A Machida; S Kishimoto; H Ohnuma; K Baba; Y Ito; H Miyamoto; G Funatsu; K Oda; S Usuda; S Togami
Journal:  Gastroenterology       Date:  1984-05       Impact factor: 22.682

6.  Putative reverse transcriptase intermediates of human hepatitis B virus in primary liver carcinomas.

Authors:  H Will; J Salfeld; E Pfaff; C Manso; L Theilmann; H Schaler
Journal:  Science       Date:  1986-02-07       Impact factor: 47.728

7.  Characterization of large surface proteins of hepatitis B virus by antibodies to preS-S encoded amino acids.

Authors:  E Pfaff; M Q Klinkert; L Theilmann; H Schaller
Journal:  Virology       Date:  1986-01-15       Impact factor: 3.616

8.  Detection of pre-S1 proteins in serum and liver of HBsAg-positive patients: a new marker for hepatitis B virus infection.

Authors:  L Theilmann; M Q Klinkert; K Gmelin; J Salfeld; H Schaller; E Pfaff
Journal:  Hepatology       Date:  1986 Mar-Apr       Impact factor: 17.425

Review 9.  The hepatitis B virus.

Authors:  P Tiollais; C Pourcel; A Dejean
Journal:  Nature       Date:  1985 Oct 10-16       Impact factor: 49.962

10.  Nonoverlapping T and B cell determinants on an hepatitis B surface antigen pre-S(2) region synthetic peptide.

Authors:  D R Milich; A McLachlan; F V Chisari; G B Thornton
Journal:  J Exp Med       Date:  1986-08-01       Impact factor: 14.307
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